Project Grant R01AR087128
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of Pennsylvania a $719,758 Project Grant on July 10, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the role of nuclear myotubularin (MTM1) in muscle development and X-linked myotubular myopathy (XLMTM). The research will be conducted through June 30, 2030, with the goal of understanding how MTM1 gene...
- Federal Grant Award Summary The University of Pennsylvania received a $2.06 million Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective June 1, 2026 through May 31, 2030. This award funds research to elucidate the role of protein translation efficiency in T cell adaptation to human skin, with specific focus on tissue-resident memory T cells (TRM)...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Pennsylvania a $857,127 Project Grant on June 3, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate mitochondrial respiration and growth plate chondrocyte biology. The research project, extending through April 30, 2030, examines how bioenergetic metabolism—specifically glycolysis and oxidative phosphorylation...
- Federal Grant Award Summary The University of Pennsylvania received a $164,190 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective November 27, 2025, with a completion date of May 31, 2030. The research project, titled "Modulating Synovial Mechanobiology to Mitigate Disease Progression in Osteoarthritis," will be conducted at the institution's Philadelphia, Pennsylvania facility. This award supports biomedical research...
- Federal Project Grant Award Summary The University of Pennsylvania received a $646,506 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 5, 2025, through June 30, 2030. This award supports the development of dual-action nanoparticle-loaded microparticles designed to address osteoarthritis (OA) treatment through an innovative...
- Federal Grant Award Summary Pennsylvania State University, doing business as Penn State Milton S. Hershey Medical Center, received a $1.948 million Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) awarded on September 1, 2025, with a completion date of August 31, 2028. The grant funds research into post-transcriptional regulation of gene expression during bone...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of Delaware a $666,825 Project Grant on September 1, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the structural and functional roles of muscle-subtendon units in Achilles tendinopathy. The research will extend through June 30, 2030, utilizing advanced biomechanical sensors, magnetic resonance imaging...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1.85 million Project Grant to the University of California, San Diego to investigate the role of lysine acetylation in skeletal muscle contractile function. The award, announced September 15, 2025, with completion targeted for August 31, 2028, will deliver research findings on how post-translational modifications of contractile proteins regulate skeletal muscle force...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pennsylvania a Project Grant of $333,116 under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2026. This award supports biomedical research directed toward understanding aging processes and age-related diseases. The research project investigates the relationship between telomere dysfunction, aging, and intestinal stem cell (ISC) niche function, with the goal of...
- Federal Grant Award Summary The University of Pennsylvania received a $723,105 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on May 15, 2026, with a completion date of February 28, 2031. This award supports research aimed at targeting Activin A signaling to enhance bone repair, addressing the clinical challenge of delayed or nonunion fractures that occur in 5-10% of fracture cases, with particular prevalence among geriatric populations. The...
The University of Pennsylvania received a $546,145 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective May 1, 2026 through March 31, 2031. This research initiative delivers scientific investigation into the molecular mechanisms of telomere function in muscle cells, specifically examining how telomere-associated proteins regulate muscle stem cell (MuSC) behavior and tissue regeneration. The project generates fundamental knowledge regarding the extra-telomeric functions of TRF2 (Telomere Repeat Factor 2), a key telomere-capping protein, through controlled laboratory studies employing genetic tools designed to evaluate protein function in healthy, injured, and diseased skeletal muscle contexts. The deliverables include peer-reviewed research outputs characterizing previously undocumented roles of TRF2 in maintaining stem cell identity and regulating regenerative myogenesis following acute and chronic muscle injuries. Research findings will identify novel protein interactions and mechanistic pathways relevant to muscle tissue restoration and dysfunction in conditions such as muscular dystrophy. These outputs are expected to advance therapeutic strategies for promoting muscle regeneration and functional recovery in both healthy and diseased states, addressing a critical gap in understanding how telomeric proteins influence the high regenerative capacity of skeletal muscle tissue independent of their conventional chromosomal protection functions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $546.1k | 5/4/26 |