Project Grant R01AR086380
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Tissuerate Inc. $1.262 million on September 5, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop a modular synthetic bone graft technology for large bone defects. Tissuerate will develop and validate a 3D-printed modular bioactive synthetic bone graft based on proprietary osteoinductive HYTEC technology, which enables sustained delivery of BMP2 and has...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Leland Stanford Junior University $200,478 on September 10, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds research into the origin and fate of adipo-CAR (CXCL12-abundant reticular) cells in PTH1R-OSXKO mice. The work addresses how parathyroid hormone receptor signaling influences mesenchymal stem cell lineage allocation between bone-forming...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $1.696 million to Poly Orth International on September 15, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds translational pre-clinical research and development of a 3D-printed skin and bone integrated pylon (SBIP-3D) for direct skeletal attachment of limb prostheses. The technology, developed by Poly Orth International, integrates with both residual bone...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Johns Hopkins University $671,214 on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate somatosensory nerve regulation of fracture repair. The research focuses on the role of tropomyosin receptor kinase A (TrkA)-positive sensory neurons in bone healing, specifically examining how these neurons regulate fracture repair through the release of...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Penderia Technologies Inc. $306,722 on September 19, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to fabricate and characterize a distal femoral fracture fixation plate featuring an implantable, battery-free wireless sensor for intra- and postoperative monitoring of fixation plate strains. The project targets personalized postoperative...
- The Department of the Army Medical Command awarded a $2,756,800 Project Grant to Stanford University under the Military Medical Research and Development program (CFDA 12.420). The award will support development of an implantable device that enables personalized, sustained release of bioagents for large bone defect reconstruction and limb salvage from June 2022 through May 2026. Under the award, Stanford will establish a sheep bone transport model and test handling of a novel intramedullary...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Leland Stanford Junior University $204,682 on September 10, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to characterize the roles of RNA-binding protein assemblies in epidermal homeostasis. The recipient will develop and apply two new crosslinking immunoprecipitation-based methods—IRCLIP-RNP and RE-CLIP—to study how RNA-binding proteins organize and...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Leland Stanford Junior University a $154,000 Project Grant effective August 1, 2025, through July 31, 2027, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award supports research applying service design methods to enhance the implementation and adoption of iGET Living, a digital graded exposure treatment (GET)...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Delaware $1,202,240 on September 24, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop and validate next-generation MRI methods for diagnosing bone fracture healing. The recipient will conduct a translational validation study employing ultrashort echo time MRI sequences and finite element–based virtual mechanical testing to quantify and...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Regents of the University of California, San Francisco $448,563 on September 5, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) for an ancillary study investigating systemic bone loss mechanisms following fracture. UCSF will conduct multimodal analysis of circulating cells and factors in blood samples collected from fracture patients at multiple timepoints...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Leland Stanford Junior University $667,829 on August 15, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop and validate an osteoinductive, biodegradable intramedullary implant as an adjunctive therapy for distraction osteogenesis in large orthopedic trauma and limb reconstruction. The project addresses a major limitation of the Ilizarov surgical technique—the prolonged bone consolidation phase lasting several months to over one year—by engineering an implant that delivers controlled, sustained release of bone morphogenetic protein-2 (BMP-2) to accelerate bone healing. Stanford's preliminary work demonstrated that the scaled-up hybrid tissue engineering construct significantly promoted bone regeneration in a sheep acute shortening-lengthening model compared to standard surgical treatment, with histological evaluation of critical organs confirming safety and minimal off-target effects. The funded work encompasses development and characterization of a clinically relevant, scaled-up version of the implant and validation of its safety and efficacy in a sheep model. Performance occurs in Palo Alto, California, with an ultimate completion date of May 31, 2030. This is a Project Grant award.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $667.8k | 8/4/26 |