A hytec implantable device that enables personalized, sustained release of bioagent for large bone defect reconstruction and limb salvage

The Department of the Army Medical Command awarded a $2,756,800 Project Grant to Stanford University under the Military Medical Research and Development program (CFDA 12.420). The award will support development of an implantable device that enables personalized, sustained release of bioagents for large bone defect reconstruction and limb salvage from June 2022 through May 2026.

Under the award, Stanford will establish a sheep bone transport model and test handling of a novel intramedullary rail implant in the model. Colorado State University will receive a sub-award to create a 4cm metatarsal defect in sheep, place a 70mm x 6-7mm implant, and perform osteotomies and manual distraction over 40 days to close a 30mm proximal defect. Weekly radiographs will assess healing over a 6-month period. The research aims to transform military and civilian trauma care through innovative medical solutions.