The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $783,176 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Mayo Clinic. The purpose of this 2-year grant, effective September 20, 2024, is to develop and validate a quantitative spine imaging methodology using photon-counting detector computed tomography (PCD-CT) to comprehensively characterize bone quality in the vertebrae of patients undergoing...
This federal Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to optimize bone surface targeting of therapeutic antibodies for osteoporosis treatment. The $465,663 award, effective May 6, 2025 through March 31, 2030, will support research to increase the local concentration of monoclonal antibodies like anti-sclerostin and anti-RANKL in...
This federal Project Grant award of $765,546, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to develop a novel non-invasive method for assessing bone turnover in patients with chronic kidney disease (CKD). The project aims to evaluate a "virtual bone biopsy" approach using time-lapse high-resolution peripheral quantitative computed...
This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), provides $549,536 to the Trustees of Dartmouth College to develop an innovative 3D wearable near-infrared (NIR) spectral tomography system. The objective is to create a clinical platform capable of early prediction of residual cancer burden in breast cancer patients undergoing neoadjuvant chemotherapy. The proposed technological innovations focus...
This $394,482 federal Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) aims to develop and validate demineralized bone paper (DBP)-based human bone metabolic and senolytic assays to support bone-targeting drug discovery and treatment regimens. The proposed DBP-based models will provide predictive bone assays for screening new anti-bone-aging drugs and improving treatment strategies for cancer survivors at risk of...
This federal Project Grant award, provided by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), supports a $644,804 research project titled "Advancing Breast Cancer Risk Assessment for Black Women." The project aims to develop and validate a novel deep learning-based breast cancer risk assessment tool focused on Black women, leveraging digital breast tomosynthesis (DBT) imaging data. Key objectives include: Developing a DBT-driven...
This federal Project Grant award, totaling $1,938,605, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The objective of the award is to determine the mechanisms by which the X-linked chromatin modifying enzyme KDM5C regulates female bone mass. The research aims to investigate how loss of KDM5C affects osteoclast function, communication between osteoclasts and...
This federal Project Grant award of $219,605.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to identify the role of the mechanosensitive ion channel PIEZO1 in driving synovial fibrosis and inflammation in post-traumatic osteoarthritis (PTOA). The research will characterize the bi-directional regulation between PIEZO1 mechanotransduction and...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is developing the X-Visual, a sensor to track fracture healing in cannulated screws used for hip fracture fixation. The $299,999 award to Aravis Biotech LLC will cover the design, computational modeling, and initial testing of this innovative device that can non-invasively measure screw bending...
This federal Project Grant award of $456,808.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of advanced mass spectrometry imaging (MSI) technologies to spatially visualize proteins and glycans in musculoskeletal tissues. The primary awardee, the Buck Institute for Research on Aging, is collaborating with researchers at the University of...