The federal Project Grant award R21CA297246 was provided by the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to Dartmouth-Hitchcock Clinic, a non-profit healthcare provider and academic medical center. The $226,704 award, granted from January 1, 2025 to December 31, 2026, supports research to develop a novel magnetic nanoparticle heating system that uses low-frequency alternating magnetic fields to efficiently deliver energy to nanoparticles...
This federal Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) supports the development of a new bio-orthogonal mid-infrared photothermal imaging approach to quantitatively measure various molecular events in cancer cells at the subcellular level. The $407,113 award to Trustees of Boston University will be used to: 1) build a library of nitrile-based probes to sense important molecular events inside cancer cells; 2) develop...
This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $554,188 to The Trustees of the University of Pennsylvania to develop novel silver telluride nanoparticle contrast agents for improved breast cancer screening via dual-energy mammography. The key objectives are to: Adapt the nanoparticle synthesis process for microfluidic chip manufacturing to enable rapid prototyping and scale-up. Characterize the microfluidic-produced...
This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), provides $399,491 to Northridge Tri-Modality Imaging Inc. to upgrade their gantry-based imaging system to incorporate bioluminescence tomography (BLT) capabilities. The upgraded system will enable 3D whole-body fluorescent, bioluminescent, and anatomical X-ray imaging of small animal cancer models, providing a comprehensive multimodal imaging...
The U.S. National Cancer Institute (NCI) awarded a $450,000 Project Grant under the CFDA 93.396 Cancer Biology Research program to The Research Foundation for the State University of New York, doing business as Stony Brook University. The project, titled "Topological Methods for Breast Tissue Quantification," aims to develop advanced algorithms and analytical techniques using topological data analysis (TDA) to extract and interpret fine-grained structural information from breast...
This $435,827 Project Grant from the National Cancer Institute (NCI) under the CFDA 93.394 Cancer Detection and Diagnosis Research program supports research conducted by New York University (NYU) School of Medicine to develop deep learning methods for analyzing mass spectrometry imaging (MSI) data. The goal is to make MSI data more accessible to existing machine learning workflows by expanding the dimensionality of the data structure to treat each metabolite or lipid as an individual "color...
This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $703,540.00 to Brigham & Women's Hospital Inc. to develop and optimize highly effective treatments for head and neck cancer using in situ implantable microdevices. The primary goals are to: Conduct a clinical study to validate the performance of the microdevice in predicting patients' clinical response to immunotherapy and chemotherapy for head and neck squamous cell...
The National Cancer Institute awarded a $684,333 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to The Trustees of Columbia University in the City of New York. The project, titled "Integrating Breast Cancer and Cardiovascular Disease Risk to Explore Decision-Making for Chemoprevention Among Racially/Ethnically Diverse Women at High Risk for Breast Cancer," aims to evaluate if patient and provider decision support that juxtaposes breast cancer...
This federal Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $670,534 to Northwestern University to develop an optical hyperspectral nanoscale chromatin analysis technology for colorectal cancer risk-stratification. The goal is to create a highly accurate, low-cost screening test that can be administered in primary care settings to identify patients who should undergo colonoscopy, with a target of 99.5% negative predictive...
This federal Project Grant award, provided by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), supports a $644,804 research project titled "Advancing Breast Cancer Risk Assessment for Black Women." The project aims to develop and validate a novel deep learning-based breast cancer risk assessment tool focused on Black women, leveraging digital breast tomosynthesis (DBT) imaging data. Key objectives include: Developing a DBT-driven...
This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), provides $549,536 to the Trustees of Dartmouth College to develop an innovative 3D wearable near-infrared (NIR) spectral tomography system. The objective is to create a clinical platform capable of early prediction of residual cancer burden in breast cancer patients undergoing neoadjuvant chemotherapy. The proposed technological innovations focus on integrating flexible circuit strips into a sleek, wearable 64-channel breast interface and applying advanced 3D image reconstruction methods enhanced with deep learning. This project aims to transition the NIR spectral tomography system from academic exploration to a clinically practical solution, with the goal of improving long-term survival outcomes for breast cancer patients. The award period is from July 10, 2024 to June 30, 2029.