Project Grant R01AR085137
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $703,634 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The Regents of the University of California, San Francisco (UCSF). The grant, awarded on August 15, 2025, will fund a study to develop and validate age-relative measures of biochemical intervertebral disc health. The research aims to discover the age-course of biochemical disc composition,...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $584,330 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to Northeast Ohio Medical University (Neomed) to conduct research on the role of mitochondrial DNA leakage in intervertebral disc degeneration and associated inflammation. The project aims to investigate whether oxidative damage to mitochondrial DNA leads to its fragmentation and...
- This federal Project Grant award of $115,301 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) supports research to investigate the impact of abnormal lipid metabolism on intervertebral disc degeneration in mice. The research will comprehensively assess the mechanical properties of mouse intervertebral discs using in vivo and ex vivo testing systems, after...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,136,924 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the Rector & Visitors of the University of Virginia. The grant, awarded on July 1, 2025, is intended to support research on "Targeting Stage Specific Influxed Monocytes to Treat Acute and Chronic Back Pain". The project aims to use transgenic mouse models and a CCR2 antagonist to...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop injectable, cell-adhesive, and growth factor-presenting alginate hydrogels to enhance the therapeutic potential of mesenchymal stem cells (MSCs) for intervertebral disc (IVD) repair. The $752,620 award, spanning September 2024 to August 2026, will fund in vitro studies of MSCs...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $774,930.00 to the Regents of the University of Minnesota to develop and validate a mouse model of intervertebral disc degeneration-induced low back pain. The goal is to create a clinically representative preclinical model that can facilitate the discovery of novel non-addictive analgesics for the treatment of discogenic low...
- This $507,738.00 Project Grant was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The award supports the development and translation of a novel "Tension-Activated Annular Repair Scaffold (TARS)" to address structural and biological...
- The Regents of the University of Michigan, through its Office of Research and Sponsored Projects, was awarded a $1,425,183 Cooperative Agreement from the National Institute of Neurological Disorders and Stroke (NINDS) on September 19, 2025. The federal grant, under CFDA Program 93.279 - Drug Use and Addiction Research Programs, will fund a "SMART DESIGN STUDY USING PATIENT-BASED ALGORITHMS FOR MULTICOMPONENT THERAPY IN CHRONIC LOW BACK PAIN AND BEYOND" project. The goal of this...
- This $820,142 Project Grant was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research (CFDA 93.846) program. The grant aims to investigate the effects of early-life physical inactivity in mice on muscle quality, function, and frailty development in adulthood. Specifically, the research will examine the regulatory aspects of the extracellular matrix, muscle macrophages, and physical...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $376,310 to the University of North Carolina at Chapel Hill to develop the necessary documents and procedures to conduct a 16-week randomized controlled trial. The trial will test the efficacy and biochemical mechanisms of a dietary intervention involving increasing omega-3 fatty acids (EPA...
This $636,198 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to decipher the roles of age and inflammation in intervertebral disc degeneration and low back pain. The University of Miami will conduct a systematic investigation to quantify how aging and inflammatory conditions impact proteoglycan biosynthesis, a key process regulating disc hydration and the ability to resist compressive loads. The research aims to identify factors that diminish proteoglycan anabolism, leading to disc degeneration. This 5-year study from September 2025 to August 2030 will provide insights into the underlying mechanisms of disc degeneration and potential therapeutic interventions for this leading cause of global disability.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $636.2k | 9/12/25 |