Project Grant R01AR084712
- This $225,000 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support research to understand the biological mechanisms underlying calcium pyrophosphate deposition disease (CPPD), a common yet understudied age-related joint disease affecting over 30 million people worldwide. The research aims to develop advanced animal models to study CPPD disease progression and identify potential molecular pathways and therapeutic interventions. By elucidating the...
- This federal Project Grant award of $664,933 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the cellular and molecular mechanisms of IL-17A in the pathogenesis of psoriatic arthritis. The research will utilize a novel animal model to define the early pathogenic pathways driven by IL-17A that contribute to joint and skin inflammation,...
- The $735,372 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research Program (CFDA 93.846) supports research to identify the key transcription factors and cytokine signals that regulate the expression of inflammatory chemokine receptors on T cells in chronic autoimmune conditions. The goal is to elucidate the dominant pathways controlling coordinated T cell migration to...
- This Project Grant award of $139,895.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research into the link between inflammatory arthritis and the development of cardiovascular disease. The key objectives are to investigate whether "trained immunity" - the phenomenon where innate immune cells become reprogrammed to respond more efficiently to a...
- This federal Project Grant award, valued at $164,830.00 and provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research led by Dr. Alexis Ogdie at the University of Pennsylvania. The primary objectives are to: 1) quantify the impact and interrelationships of potentially modifiable risk factors, including obesity, depression, and anxiety, on treatment response...
- This federal Project Grant award of $172,584.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting a 5-year research career development program. The award recipient, The Trustees of Columbia University in the City of New York, will utilize multi-omics analyses to prioritize potentially causal genes associated with systemic sclerosis (SSc), a serious autoimmune...
- The federal Project Grant award titled "Immune Cell Contributions to Inflammatory Arthritis" is funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The $735,460 award to Vanderbilt University Medical Center will support research to investigate the roles of B cells and inflammatory cytokines in the pathogenesis of psoriatic arthritis (PSA) using a mouse model...
- The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $529,616 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Brigham & Women's Hospital Inc. to conduct research on the role of Notch signaling and fibrosis in treatment-resistant rheumatoid arthritis. The project aims to define the molecular mechanisms by which Notch signaling regulates transforming growth factor beta (TGF-β) signaling in...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $228,218 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct the "SGLT2I AS NOVEL GOUT CARE (SAVE-CARE): A RANDOMIZED CONTROLLED TRIAL". The project aims to evaluate the use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) as a novel...
- This federal Project Grant award, valued at $1,901,310.00 and provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research project aims to investigate how skin inflammation drives the development of psoriatic arthritis, a condition that affects up to one-third of individuals with psoriasis. The project will use a novel mouse model to study the...
This federal Project Grant award of $777,869 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) supports a randomized, double-blind, controlled, multi-center clinical trial to investigate the use of colchicine in treating Calcium Pyrophosphate Deposition Disease (CPPD), a prevalent but underserved form of inflammatory arthritis. The goal is to better understand colchicine's impact on the NLRP3 inflammasome and downstream pathways, which play a key role in CPPD and cardiovascular disease. The awardee, Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, will conduct this critical research over a 5-year period from August 2025 to July 2030. This work aligns with the NIAMS Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), which supports scientific investigations into the understanding, prevention, and treatment of various medical conditions affecting joints, muscles, bones, and skin.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $777.9k | 7/31/25 |