This Project Grant award of $170,101 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to characterize the spatial heterogeneity of synovial inflammation in rheumatoid arthritis (RA). The research aims to 1) identify the spatial underpinnings of known RA subtypes and define new spatially-informed RA subtypes, and 2) build a map of the different types of...
This Project Grant award of $147,917 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to improve identification of cardiovascular disease risk in patients with rheumatoid arthritis (RA). The key objectives are to assess the utility of high-sensitivity cardiac troponin testing and coronary artery calcium screening to better stratify RA patients for...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund a research project titled "A NOTCH-MEDIATED FIBROGENIC PROGRAM DRIVES TREATMENT FAILURE IN RHEUMATOID ARTHRITIS." The $529,616 award, effective June 1, 2025, aims to define the role of Notch-driven fibrogenesis in treatment failure for rheumatoid arthritis (RA). The project...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $599,693 to The Hospital For Special Surgery Fund, Inc. (HSS Foundation) from August 1, 2024 to July 31, 2029. The award supports research to elucidate molecular pathways and mechanisms that regulate myeloid cell function and osteoclastogenesis, with the goal of developing new...
This $358,000 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research at Brigham & Women's Hospital to elucidate social determinants of health and mental health needs in order to achieve equity in rheumatic disease care. The award will fund a 2-year study that leverages data from the All of Us research program to: Assess the effects of...
This Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the role of reverse transendothelial migration of neutrophils in inflammation resolution. The $366,797 award, with a project period from Sep 24, 2024 to Aug 31, 2026, aims to provide new insights into the mechanisms by which certain inflammatory mediators,...
This $664,933 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the cellular and molecular mechanisms of interleukin-17A (IL-17A) in the pathogenesis of psoriatic arthritis. The research aims to define the early cellular and molecular pathways that drive IL-17A-induced joint and skin inflammation, enthesitis, fingernail psoriasis,...
This $548,828 Project Grant was awarded on September 21, 2023 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant was awarded to Knoubis Bio Inc., a for-profit organization based in California, to support research on a non-immunosuppressive disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis. The project aims to develop a new therapeutic approach...
This Project Grant award with ID R01AR084627 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The $735,372 award supports research to identify transcription factors and cytokines that regulate the expression of inflammatory chemokine receptors on T cells, which contribute to their migration to sites of inflammation in chronic autoimmune conditions like...
This federal Project Grant award of $735,460.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA Program 93.846, Arthritis, Musculoskeletal and Skin Diseases Research. The award will fund research to study the role of B cells in the pathogenesis of psoriatic arthritis (PsA), a type of inflammatory arthritis characterized by joint inflammation, bone erosion, and disability. The key objectives are to: 1) Demonstrate that proinflammatory...