Project Grant R01AR084848
Award Date
5/15/25
Completion Date
3/31/30
Dollars Obligated
$665K
Similar Awards
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $383,570 to Temple University to conduct research on interleukin-36 (IL-36) cytokine activation and inactivation mechanisms. The project aims to improve understanding of IL-36 functions and their role in inflammatory conditions, such as atopic dermatitis, psoriasis, and skin infections,...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $735,460 to Vanderbilt University Medical Center (VUMC) to investigate the role of B cells in the pathogenesis of psoriatic arthritis (PSA). The key objectives are to: 1) demonstrate that the PSA phenotype in a mouse model is mediated by pro-inflammatory IL-6-producing B effector cells that...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $599,693 to support research into molecular pathways and mechanisms that regulate myeloid cell function and osteoclastogenesis under pathological inflammatory conditions. The research aims to elucidate how inflammation, particularly in the context of orthopedic periprosthetic...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $139,895 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Brigham & Women's Hospital Inc. in Boston, MA. The grant aims to investigate the role of "trained immunity" in linking inflammatory arthritis to the development of cardiovascular disease. Specifically, the research will test the hypothesis that inflammatory responses in...
This federal Project Grant award, totaling $242,310, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports research at Rockefeller University to investigate the long-term systemic consequences of type 2 skin inflammation on epithelial stem cells. Specifically, the research aims to define the cellular mechanisms that distinguish inflammatory...
This Project Grant award for $673,729.00, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to define the impact of dietary conjugated linoleic acid (CLA) on the formation of nitro-fatty acids in skin tissues and establish their protective effects on psoriasis, an autoimmune skin disease. The research team at the University of Pittsburgh aims to...
This federal Project Grant award of $170,101 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to characterize the spatial heterogeneity of synovial inflammation in rheumatoid arthritis (RA). The principal investigator at Brigham & Women's Hospital Inc. will use advanced statistical techniques and artificial intelligence to identify the spatial...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $735,372 to Brigham & Women's Hospital Inc. to conduct research on T cell expression of inflammatory chemokine receptors in chronic autoimmune conditions. The research aims to identify transcription factors and cytokines that regulate the expression of key chemokine receptors,...
This Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to characterize the inflammatory pathologies underlying axial psoriatic arthritis (AxPsA) using total-body positron emission tomography/computed tomography (TB-PET/CT) imaging. The $239,488 award, with a project period from December 2024 to November 2027, will be used by the University...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $295,294 to Biotherapeutics, Inc. for the development of a novel first-in-class topical immunoregulatory therapeutic for the treatment of plaque psoriasis. The key objectives are to: 1) evaluate the permeability and long-term stability of the topical drug product formulation, 2) compare the...