Project Grant R01AR082864
Award Date
8/9/24
Completion Date
5/31/29
Dollars Obligated
$594K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
St Paul, MN 55108, USA
Similar Awards
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $206,023 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Cornell University to investigate mechanotransduction pathways in injured cartilage. The project aims to determine how local peak strain magnitude and manipulation of calcium-dependent signaling or mitochondrial bioenergetics affect the distribution of chondrocyte phenotypes after impact injury, using a novel...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $618,629 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Regents of the University of Colorado to establish a new "microphysiological joint-on-chip" system. The objective is to create a realistic human joint model that can support mechanistic study of arthritic diseases and rapid testing of candidate treatments. The researchers plan to develop...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the molecular regulatory mechanisms of a cartilage-enriched G protein-coupled receptor (GPCR) named ADGRG6 in maintaining joint cartilage and homeostasis. The $426,889 award, spanning Apr 2025 to Mar 2030, will fund work by researchers at the University of...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded Vanderbilt University a $393,412 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to develop engineered cells as agents for treating osteoarthritis. The project aims to leverage advanced cell design platforms to create synthetic receptor-controlled, joint-resident cells that can detect cartilage degeneration and then upregulate the expression of transgenes to promote...
This federal Project Grant award, valued at $626,879.00, was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to explore a novel mouse model of large-scale bone regeneration to unravel the cellular and molecular mechanisms governing the initiation and coordination of bone repair following extensive injuries. Specifically, the research will...
This $483,070 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 "Arthritis, Musculoskeletal and Skin Diseases Research" supports research into the dynamics of bone extracellular matrix (ECM) assembly and resorption. The study aims to investigate how osteogenic cellular dynamics, differentiation, and cell fate are integrated with collagen assembly and mineralization, as well as how osteoclast bone resorption...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop optical redox imaging (ORI) as a diagnostic and evaluative tool for osteoarthritis (OA) and other cartilage diseases. The $359,207 award, valid from September 1, 2024 to August 31, 2028, will be used to: 1) develop a stress test to diagnose cartilage disease based on changes in ORI...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $196,460 Project Grant (CFDA 93.846) to the University of Pittsburgh to test a novel microphysiological system for studying neuro-immune interactions in osteoarthritis pain. The project aims to understand the influence of synovial-like tissue inflammatory molecules on innervating neurons, assess the role of chemokines and neuropeptides on pain and inflammation, and develop a platform for testing...
This $578,944 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The primary objective is to decipher the genetics of osteoarthritis (OA) susceptibility, heterogeneity, and progression. The research aims to identify new and fine-map known genetic loci associated with OA and total joint replacement, disentangle OA heterogeneity by...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $605,253 to The Trustees of the University of Pennsylvania to investigate the mechanical crosstalk between the intervertebral disc and adjacent facet joints during spinal degeneration and repair. The research aims to characterize the progression of facet osteoarthritis following disc...