The federal Project Grant award R21AR085398, totaling $1,288,152.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award aims to develop a high-throughput screening approach, named "JOINTSEQ", to identify nanoparticles (NPs) that can target specific cell types in osteoarthritis (OA) joints. The research team, led by Tufts University School of...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $1,657,392.00 to the University of Pittsburgh to conduct research on repurposing FDA-approved drugs for the treatment of osteoarthritis (OA). The research aims to leverage high-throughput screening in human cell-derived microphysiological models to identify disease-modifying OA drugs...
This federal Project Grant award of $456,808.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of advanced mass spectrometry imaging (MSI) technologies to spatially visualize proteins and glycans in musculoskeletal tissues. The primary awardee, the Buck Institute for Research on Aging, is collaborating with researchers at the University of...
The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $410,920 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research (CFDA 93.846) program to The Washington University in St. Louis. The grant will fund a 5-year research project to investigate risk factors for end-stage glenohumeral (shoulder) osteoarthritis, with the objectives of determining associations between occupational exposures and shoulder arthroplasty risk,...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $618,629 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Regents of the University of Colorado to establish a new "microphysiological joint-on-chip" system. The objective is to create a realistic human joint model that can support mechanistic study of arthritic diseases and rapid testing of candidate treatments. The researchers plan to develop...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded Vanderbilt University a $393,412 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to develop engineered cells as agents for treating osteoarthritis. The project aims to leverage advanced cell design platforms to create synthetic receptor-controlled, joint-resident cells that can detect cartilage degeneration and then upregulate the expression of transgenes to promote...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $196,460.00 to the University of Pittsburgh to test a novel microphysiological system for studying neuro-immune interactions in osteoarthritis pain. The project aims to use this miniature knee joint system to understand the influence of synovial inflammatory molecules on innervating...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $412,610.00 to the Oklahoma Medical Research Foundation (OMRF) to investigate associations between the peripheral blood microbiome and knee osteoarthritis. The key objectives are to determine if baseline peripheral blood bacterial DNA patterns can predict future radiographic and...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $1,066,302 to create a knowledgebase to promote and facilitate the use of the Osteoarthritis Initiative (OAI) to accelerate discoveries. The knowledgebase will extract, accumulate, organize, annotate, and link information related to the OAI, a 16-year observational study with...
This $142,000 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The grant supports research to investigate the mechanisms underlying sex differences in the development of advanced osteoarthritis (OA) pain in a mouse model. The key objectives are to: Determine pathological sprouting of sensory nerves in the knee joint and surrounding muscle of male and female mice with mid-stage and...