The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $220,224 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Regents of the University of Colorado, operating as the University of Colorado, with a period of performance from July 4, 2024 to August 31, 2027. The funding will support the development of granular hydrogels for the controlled delivery of immunomodulatory and angiogenic extracellular vesicles to enhance...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,657,392 Project Grant under CFDA 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research) to the University of Pittsburgh. The grant funds research to repurpose FDA-approved drugs for the treatment of osteoarthritis (OA) using high-throughput screening in microphysiological models. The project aims to define the capacity of FDA-approved drugs to reverse cartilage-driven and inflammation-driven OA...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded Vanderbilt University a $393,412 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to develop engineered cells as agents for treating osteoarthritis. The project aims to leverage advanced cell design platforms to create synthetic receptor-controlled, joint-resident cells that can detect cartilage degeneration and then upregulate the expression of transgenes to promote...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $123,040 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate the therapeutic role of the NFAT1 transcription factor in osteoarthritis. The 5-year project, which began on August 1, 2024, aims to evaluate the potential of AAV-delivered NFAT1 gene therapy in treating...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research into the molecular regulatory mechanisms of a cartilage-enriched G protein-coupled receptor (GPCR) named ADGRG6 in maintaining joint homeostasis and preventing osteoarthritis (OA). The $426,889 award, effective from April 10, 2025 to March 31, 2030, will enable the University...
The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $410,920 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research (CFDA 93.846) program to The Washington University in St. Louis. The grant will fund a 5-year research project to investigate risk factors for end-stage glenohumeral (shoulder) osteoarthritis, with the objectives of determining associations between occupational exposures and shoulder arthroplasty risk,...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,066,302 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the University of Massachusetts Medical School. The grant, effective April 1, 2025 through March 31, 2029, will fund the creation of a biomedical knowledgebase to promote and facilitate the use of the Osteoarthritis Initiative (OAI), a rich 16-year observational study with comprehensive...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $206,023 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Cornell University to investigate mechanotransduction pathways in injured cartilage. The project aims to determine how local peak strain magnitude and manipulation of calcium-dependent signaling or mitochondrial bioenergetics affect the distribution of chondrocyte phenotypes after impact injury, using a novel...
This $548,828 Project Grant was awarded on September 21, 2023 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant was awarded to Knoubis Bio Inc., a for-profit organization based in California, to support research on a non-immunosuppressive disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis. The project aims to develop a new therapeutic approach...
This $578,944 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The primary objective is to decipher the genetics of osteoarthritis (OA) susceptibility, heterogeneity, and progression. The research aims to identify new and fine-map known genetic loci associated with OA and total joint replacement, disentangle OA heterogeneity by...