Project Grant R01AI202913
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $780,615 on July 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on immune signaling and antibacterial defenses controlled by mycobacterial PE/PPE proteins. The research addresses mechanisms by which Mycobacterium tuberculosis manipulates host cell biology to establish infection. MTB secretes over 100 proteins that block macrophage...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, $672,540 on April 17, 2026, for novel pediatric tuberculosis diagnostics using host and microbial biomarkers under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project develops diagnostic tools to address tuberculosis as a leading cause of death in children worldwide, with children accounting for an estimated 14 percent...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, $2.060 million on September 11, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate host-bacterial interactions determining the spectrum of Mycobacterium tuberculosis transmission. The research examines the biology of MTB infection across exposed household contacts and "resister"...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $8.74 million on September 10, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to establish and operate a consortium supporting rigorous evaluation and development of early-stage tuberculosis diagnostics, including drug susceptibility tests. The award funds a fast-paced pipeline combining technology scouting, development mentoring, and clinical testing of TB...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, $894,019 on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to model and manipulate transcription factor activities to shorten tuberculosis therapy and improve TB diagnostics. The research develops machine learning models trained on transcription factor activity profiles to predict Mycobacterium tuberculosis...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey (doing business as RBHS-School of Nursing) $811,772 on June 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify drug tolerance mechanisms in Mycobacterium tuberculosis glpK mutants and develop improved treatments for drug-tolerant persister bacilli. The research uses an MTB H37RV glpK knockout strain to determine genes and genetic pathways...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $431,750 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define the impact of phosphatidylserine-targeting antibodies on T cell function in HIV-1 infection. The research investigates how phosphatidylserine-reactive antibodies, produced endogenously during HIV-1 infection, influence T cell dysregulation and immune activation in people...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $235,500 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize mechanisms of foam cell formation in tuberculosis and cryptococcosis infections. The recipient, operating as RBHS-School of Nursing, will conduct comparative analysis of pathogen-associated molecular patterns (PAMPs) and macrophage pattern recognition receptors (PRRs)...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey (doing business as RBHS-School of Nursing) $764,590 on February 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the ontogeny and functions of trained macrophages in type 2 immunity. The research addresses helminth parasite infections affecting an estimated 2 billion people globally and examines how type 2 inflammatory responses balance...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $647,356 on June 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of GPR132 in regulating CD8 T cell responses during infection and cancer. The research aims to determine how GPR132, a G protein–coupled receptor that detects oxidized endogenous and microbial lipids, regulates CD8 T cell expansion and memory differentiation. The...
The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $813,248 on August 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of neutrophils in tuberculosis pathogenesis and post-TB lung disease. The research, conducted at the Newark, New Jersey location and extending through July 31, 2031, defines how early neutrophil recruitment, activation, and metabolic reprogramming regulate TB pathogenesis and post-TB lung disease. Aim 1 investigates how early neutrophil influx into the lung microenvironment influences the function of macrophages, T cells, and alveolar epithelial cells, shaping granuloma development, necrosis, and tissue integrity, using depletion and induction strategies in susceptible and resistant mouse strains and spatiotemporal mapping in rabbits. Aim 2 establishes how neutrophil metabolic reprogramming, particularly fatty acid oxidation, drives dysfunction and persistence within lesions and amplifies tissue injury by spatially profiling neutrophil metabolic states across distinct granuloma subtypes and experimentally manipulating fatty acid oxidation in vivo. Aim 3 evaluates neutrophil-targeted host-directed therapies, including CXCR2 antagonists and netosis inhibitors, in mouse and rabbit models. The award supports biomedical research addressing infectious disease through the Allergy and Infectious Diseases Research program, which funds scientists and research organizations studying infectious, immunologic, and allergic diseases to advance scientific knowledge and improve health outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $813.2k | 8/19/26 |