Project Grant R21AI194657
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $813,248 on August 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of neutrophils in tuberculosis pathogenesis and post-TB lung disease. The research, conducted at the Newark, New Jersey location and extending through July 31, 2031, defines how early neutrophil recruitment, activation, and metabolic reprogramming regulate TB...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $780,615 on July 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on immune signaling and antibacterial defenses controlled by mycobacterial PE/PPE proteins. The research addresses mechanisms by which Mycobacterium tuberculosis manipulates host cell biology to establish infection. MTB secretes over 100 proteins that block macrophage...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey (doing business as RBHS-School of Nursing) $764,590 on February 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the ontogeny and functions of trained macrophages in type 2 immunity. The research addresses helminth parasite infections affecting an estimated 2 billion people globally and examines how type 2 inflammatory responses balance...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $431,750 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define the impact of phosphatidylserine-targeting antibodies on T cell function in HIV-1 infection. The research investigates how phosphatidylserine-reactive antibodies, produced endogenously during HIV-1 infection, influence T cell dysregulation and immune activation in people...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, $2.060 million on September 11, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate host-bacterial interactions determining the spectrum of Mycobacterium tuberculosis transmission. The research examines the biology of MTB infection across exposed household contacts and "resister"...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey (doing business as RBHS-School of Nursing) $811,772 on June 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify drug tolerance mechanisms in Mycobacterium tuberculosis glpK mutants and develop improved treatments for drug-tolerant persister bacilli. The research uses an MTB H37RV glpK knockout strain to determine genes and genetic pathways...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $647,356 on June 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of GPR132 in regulating CD8 T cell responses during infection and cancer. The research aims to determine how GPR132, a G protein–coupled receptor that detects oxidized endogenous and microbial lipids, regulates CD8 T cell expansion and memory differentiation. The...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, $672,540 on April 17, 2026, for novel pediatric tuberculosis diagnostics using host and microbial biomarkers under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project develops diagnostic tools to address tuberculosis as a leading cause of death in children worldwide, with children accounting for an estimated 14 percent...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded Rutgers The State University of New Jersey (Robert Wood Johnson Health Sciences School of Nursing) $421,098 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R21AI196915). The recipient will conduct research to identify and investigate CD4+ T cell clonotypes comprising a polyclonal repertoire against aeroallergen in a...
- The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $235,500 on June 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to establish proof-of-concept for nucleotide-competing inhibitors (NCIs) targeting HIV-1 and LINE-1 reverse transcriptases. The research develops NCIs that block polymerase active sites without requiring incorporation into nucleic acids, addressing limitations of existing nucleoside...
The National Institute of Allergy and Infectious Diseases awarded Rutgers The State University of New Jersey $235,500 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize mechanisms of foam cell formation in tuberculosis and cryptococcosis infections. The recipient, operating as RBHS-School of Nursing, will conduct comparative analysis of pathogen-associated molecular patterns (PAMPs) and macrophage pattern recognition receptors (PRRs) that trigger neutral lipid accumulation in infected macrophages. Specific Aim 1 identifies lipogenic effects on macrophages from purified and synthetic components of Cryptococcus neoformans and Mycobacterium tuberculosis, including cell-wall-defective mutants. Specific Aim 2 uses CRISPR interference technology to assess infection-induced lipid droplet accumulation in PRR knockdown macrophage mutants, mapping the networks of receptors implicated in lipid accumulation across both infections. The work employs murine macrophage cell lines for both aims. Performance occurs in Newark, New Jersey. The period of performance runs from September 1, 2026, through August 31, 2028. This R21 grant classification supports exploratory developmental research designed to generate preliminary findings on disease-specific and shared mechanisms underlying foam cell biogenesis in these two pulmonary infectious diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $235.5k | 8/18/26 |