The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $4,760,584 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program to the Regents of the University of California, San Francisco (UCSF) for the "RAPID RESEARCH FOR DIAGNOSTICS DEVELOPMENT IN TB NETWORK: EPISODE 2 (R2D2 TB NETWORK II)" project. The goal of this project is to address the critical unmet need for better tuberculosis (TB) diagnostics in high-burden...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,041,944 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Rutgers, The State University of New Jersey. The grant will support research to understand the mechanisms underlying heterogeneous transmission of Mycobacterium tuberculosis (MTB) strains, as well as the immune responses of individuals who resist MTB infection despite exposure. The research aims to identify potential...
The National Institute of Allergy and Infectious Diseases (NIAID), through its Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $238,500 project grant to the University of California, San Diego (UC San Diego) to develop a novel electrochemical lateral flow assay (ELFA) for the point-of-need diagnosis of tuberculosis (TB). The objective is to create a highly sensitive and specific blood or urine test that can accurately distinguish active TB disease from...
This $781,369 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The funding supports research to investigate the role of B cells in regulating lung inflammation and disease progression in chronic tuberculosis (TB). The research aims to elucidate how B cells drive CD4+ T cell expansion and pro-inflammatory responses, as well as how B cells may restrict...
This $743,651 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to validate the use of plasma cell-free RNA (cfRNA) as a biomarker for the diagnosis of tuberculosis (TB) and monitoring of treatment. The grant will support the validation of cfRNA signatures in a large patient cohort of 1,378 adults across five countries, and the comparison of cfRNA diagnostic accuracy against...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $536,148 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Tufts University School of Medicine to conduct research on integrating point-of-care urine isoniazid testing into routine tuberculosis (TB) care in India. The research aims to facilitate early and accurate identification of TB patients who are at risk of poor outcomes, including death and disease recurrence, due to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), Catalog of Federal Domestic Assistance (CFDA) 93.855 Allergy and Infectious Diseases Research program, aims to inform the development of a simple, highly sensitive and specific, non-sputum-based point-of-care test (POCT) for tuberculosis (TB) diagnosis. The $850,711 award to Albert Einstein College of Medicine, located in Bronx, NY, will support the investigation of a panel of six monoclonal...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $253,497 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to The Trustees of Columbia University in the City of New York for the project "MOBILIZING INNOVATIVE STRATEGIES TO IMPROVE TB DIAGNOSIS AND RETENTION IN THE TB CARE CASCADE FOR MIGRANT COMMUNITIES IN NEW YORK CITY". The project aims to evaluate innovative methods, including a mobile diagnostic platform...
This federal Project Grant award of $743,817 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to delineate T cell receptor (TCR) families associated with protection from progression to pulmonary tuberculosis (TB) disease. The research will use advanced imaging techniques like fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET-CT) to identify TB-exposed household...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $813,373.00 to Rutgers, The State University of New Jersey to conduct research aimed at "Unraveling the Spectrum of Intrabacterial Amide Hydrolysis to Develop New Classes of Pyrazinoic Acid Prodrugs Against Pyrazinamide Resistant Mycobacterium tuberculosis". The 5-year project from Jun 2025 to May 2030...
The federal Project Grant award of $3,089,360 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development and evaluation of innovative tuberculosis (TB) diagnostic platforms and assays. The 5-year project, awarded to Rutgers, The State University of New Jersey, aims to accelerate promising TB diagnostics through a fast-paced pipeline that includes technology scouting, development mentoring, and rigorous clinical testing at a global network of research sites. The program also features an analytical laboratory core to optimize new TB diagnostic technologies before and after clinical studies. This award addresses the critical need for improved TB case detection, especially in hard-to-diagnose populations, and rapid identification of drug resistance to guide personalized treatment and protect the efficacy of newer TB drugs.