This Project Grant award of $437,477.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop a "human lymph node-on-a-chip" microphysiological system. The goal is to create an in vitro model that accurately replicates the key functional compartments, cell types, and dynamic processes of the human lymph node environment to provide a more clinically relevant platform for...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) totaling $831,755 supports research to investigate the role of lung-resident macrophage subsets, particularly nerve- and airway-associated macrophages (NAMs), in regulating type 2 immune responses and tissue homeostasis. The research aims to elucidate the mechanisms by which these macrophage populations mediate protective...
This Project Grant award, valued at $1,500,314 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on engineering a hydrogel-based human immune organoid to generate antigen-specific germinal center (GC) B cells and enable forced affinity maturation ex vivo. The goal is to examine the in vivo engraftment of the engineered human B cells delivered via injectable gels. This innovative...
This federal Project Grant award, R21AI186033, in the amount of $244,440.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to define the chemotactic cues, receptors, and target cells that orchestrate the homing and clustering of Ly6C+ monocytes at sites of microbial pathogen infections. The research aims to elucidate the mechanisms by which these...
This $693,465 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research by Cornell University to construct a molecular atlas of T cell development in lymph nodes and determine how cellular interactions and communication networks change during CD8+ T cell priming throughout childhood. The research aims to provide a new paradigm for understanding T cell activation and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $837,497 to Yale University over a 5-year period ending April 30, 2030. The project aims to elucidate the role of the PI3K-gamma enzyme in regulating the antibody response, with a focus on understanding the molecular mechanisms by which B cells utilize PI3K-gamma signaling to differentiate into antibody-secreting...
This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research program supports research to investigate how distinct age-associated B cell subsets can protect the aged from influenza. The project aims to determine the potential of different age-associated B cell subsets to respond to influenza infection and generate antibody-secreting cells, B cell memory, and long-lived...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $246,623 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to New York University School of Medicine to conduct research on the molecular control of tolerogenic dendritic cell function. The overarching goal is to delineate the molecular mechanisms underlying the tolerogenic function of dendritic cells and their role in promoting immune tolerance. The 2-year project, spanning November 2024 to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $658,657 to support research aimed at understanding the biophysical mechanisms by which protein condensates functionally couple with ordered lipid domains in T-cells. The primary awardee, the University of Virginia, will conduct an integrated investigation spanning biophysical characterization, live-cell...
This federal Project Grant award of $606,501 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the role of the BAF chromatin remodeling complex in regulating germinal center B cell responses. The overarching goal is to provide comprehensive mechanistic insights into how the ARID1A-dependent canonical BAF complex (ARID1A-cBAF) establishes the germinal center transcriptional...