Project Grant R01AI189793
Award Date
7/25/25
Completion Date
6/30/29
Dollars Obligated
$3.5M
Federal Agency
National Institute of Allergy and Infectious Diseases
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
New York, USA
Similar Awards
This Project Grant award, totaling $764,591, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project aims to study the differential regulation of cell cycle entry and apoptosis in cytolytic lymphocytes, particularly natural killer (NK) cells, with a focus on understanding how genetic variants affecting DNA replication (the "replisome") can impair NK cell function. The...
This Project Grant award, valued at $735,078, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The funding supports a 5-year research project to investigate the molecular mechanisms of innate immune memory in humans, with a focus on understanding the epigenetic determinants that enable long-lasting "trained immunity" in myeloid and lymphoid progenitor cells. The...
This Project Grant award of $666,567 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of California, Los Angeles (UCLA) to investigate the transcriptional regulation of human natural killer (NK) cell function in response to viral infections, such as human cytomegalovirus (HCMV). The key objectives are to determine the mechanisms by which the transcription factor MEF2C regulates NK cell...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $220,000 to the Fred Hutchinson Cancer Center to conduct research on natural killer (NK) cell memory responses to HIV. The key objectives are to use a novel lineage tracing method called ASAP-seq to identify and characterize long-lived, HIV-specific NK memory cell clones in a unique longitudinal cohort of...
This federal Project Grant award for $246,623.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research at New York University School of Medicine to study the molecular control of tolerogenic dendritic cell function. The research aims to characterize the dendritic cell subset responsible for maintaining T cell tolerance, including investigating aberrant cytokine...
This federal Project Grant award of $643,718 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how interferon-regulatory factors (IRFs) and STAT transcription factors remodel the epigenome and chromosome organization of macrophages to reprogram their immune responses. The research aims to: 1) dissect the roles of innate immune IRFs in de novo enhancer formation, 2)...
This Project Grant award of $1,454,386.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports fundamental research to better understand the epigenetic regulation of the HIV-1 viral RNA cap. The research aims to define the structural basis of HIV cap hypermethylation and its linkage to modulating host innate immune signaling, with the goal of developing new treatments to neutralize deleterious...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $318,085 to support research on the role of antibodies in controlling virus infections through Fc-dependent mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The research aims to elucidate the...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $223,068 Project Grant to Loyola University of Chicago to investigate the origin, differentiation, and function of tissue-resident natural killer (NK) cells in the uterine mucosa. The 2-year project, running from July 2025 to June 2027, aims to elucidate the signals that drive the differentiation of circulating NK cells into...
This Project Grant award of $405,497.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to develop a compact viral system for robust, concurrent CRISPR activation and interference (CRISPRa/i) in primary murine immune cells. The goal is to use this system to map the gene regulatory network controlling BCL11B activation and T cell lineage commitment. Key innovations include CRISPR RNA-scaffolds to recruit...