This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) provides $242,250 to The Methodist Hospital Research Institute (HMRI) to evaluate the translational potential of two novel strategies, salivabactin and an engineered probiotic, to treat or prevent Group B Streptococcus (GBS) infections in preclinical mouse models. The primary objective is to assess the efficacy of these...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on elucidating the role of Akkermansia muciniphila in Group B Streptococcal (GBS) vaginal colonization and ascending infection. The $148,568 award will support research to investigate the specific mechanisms by which A. muciniphila promotes GBS interaction with human vaginal epithelial cells, potentially...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $216,264 to the University of Colorado-Denver to characterize the interactions between Group B Streptococcus (GBS) and Candida albicans (CA) within the gastrointestinal and female reproductive tract. The research aims to determine how CA's transcriptional reprogramming of GBS impacts vaginal colonization and disease,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $162,000 in funding to the Rector & Visitors of the University of Virginia (UVA) from September 1, 2024 to August 31, 2026. The project aims to characterize a Type VII secretion system (T7SS) in Group B Streptococcus (GBS) and investigate its role in virulence and immune response. Key objectives include...
This $926,057 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research is supporting research to understand how the gut microbiota influences immune responses, particularly B-cell development and antibody production, following vaccination. The project aims to identify gut stromal cell populations and microbial components that are crucial for enhancing stromal cell function and promoting improved...
The National Institute of Child Health and Human Development (NICHD) awarded a Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Vanderbilt University Medical Center for $769,842 on September 20, 2024. The grant will fund research to determine the efficacy of using human milk oligosaccharides (HMOs) as a dietary or chemotherapeutic strategy to prevent Group B Streptococcus (GBS) infections and improve pregnancy outcomes. The research will...
This $2,654,646 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports a multi-year program to better understand the unique characteristics of the human immune response in early life. The program aims to uncover genetic and developmental determinants of pediatric immunity, examine how immune parameters evolve over childhood, and elucidate how baseline immune states predict responses to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $489,500.00 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct research on overcoming technical obstacles in understanding the assembly and regulation of B cell antigen receptors (BCRs). The research aims to elucidate the structural details of BCR assembly and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) provides $837,644 to Michigan State University from November 2024 through October 2029. The primary objectives are to develop comprehensive libraries of synthetic oligosaccharides with varied amine/acetylation patterns of poly-β-(1-6)-N-acetylglucosamine (PNAG) and evaluate their potential as effective anti-microbial vaccine...
This $531,245 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research by Yale University to structurally and functionally characterize the sorting platform component of the type III secretion system (T3SS) in Salmonella bacteria. Through a multidisciplinary approach involving bacterial genetics, biochemistry, microscopy, and cryo-electron microscopy, the research aims to...