Project Grant K22AI170795
Award Date
9/1/24
Completion Date
8/31/26
Dollars Obligated
$162K
Federal Agency
National Institute of Allergy and Infectious Diseases
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
NEWCOMB HALL, VA 22904, USA
Similar Awards
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to determine the molecular mechanisms that cause fetal injury, preterm labor, and stillbirth during Group B Streptococcus (GBS) intraamniotic infection. The total award is $1,913,386 with a period of performance from June 14, 2024 to April 30, 2029. The research aims to: 1) determine the impact of the GBS...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $242,250 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Methodist Hospital Research Institute (HMRI) in Houston, Texas. The grant's objective is to evaluate the translational potential of two novel strategies, the antibiotic salivabactin and an engineered probiotic that hyperproduces salivabactin, to treat or prevent Group B Streptococcus (GBS) infections in preclinical...
This federal Project Grant award, valued at $148,568.00 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to elucidate the role of Akkermansia muciniphila in Group B Streptococcus (GBS) vaginal colonization and ascending infection. The award supports research to investigate the specific mechanisms by which A. muciniphila promotes GBS adherence to human vaginal epithelial cells,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $873,600.00 to the University of Colorado-Denver over 24 months to conduct research on the role of commensal bacteria in promoting mucosal colonization by Group B Streptococcus (GBS). The research aims to: 1) determine the mechanism by which the commensal bacterium Akkermansia muciniphila increases GBS...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $216,264 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to conduct research on the interkingdom synergy between Group B Streptococcus (GBS) and Candida albicans (CA) within the gastrointestinal and genital tract. The key objectives of this 2-year research project...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $400,000 to investigate how the diabetic wound environment impacts the pathogenesis of Group B Streptococcus (GBS) infections. The research aims to elucidate the specific environmental factors, including neutrophil function, hyperglycemia, and polymicrobial interactions, that contribute to GBS success in diabetic wound...
This federal Project Grant award in the amount of $189,150 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The goal of this 2-year research project is to identify new regulators of how outer membrane vesicles (OMVs) released by Gram-negative bacteria enter and deliver bacterial components into the cytosol of macrophages, leading to an inflammatory response. The research aims to bridge a...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,287,210.00 to Emory University to conduct research on the pathogenesis of Group A Streptococcus (GAS) infections. The goal is to understand how GAS virulence factors, such as the protease SpeB, manipulate cellular processes in skin keratinocytes to promote invasion and evasion of immune defenses. The research will...
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to identify and characterize the secreted proteins of Mycobacterium tuberculosis and understand their role in tuberculosis (TB) pathogenesis and immunity. The $820,246 award to the Albert Einstein College of Medicine will utilize a novel ESX5 mutant strain of the TB bacterium to investigate the...
This federal Project Grant award, valued at $453,900.00 and granted by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of a genome editing platform leveraging phage recombinases. The project aims to create a broadly applicable bacterial genetic engineering system capable of operating across a wide range of Gram-positive and Gram-negative species, including clinically relevant...