Project Grant R01AI192619
- Federal Grant Award Summary The University of Chicago received a $218,164 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 25, 2025, with completion scheduled for March 31, 2029. This award funds basic immunological research examining the developmental acquisition of memory-phenotype CD8+ T cell function. The research will characterize how CD8 memory phenotype (CD8-MP)...
- Federal Grant Award Summary The University of Chicago received a $3.02 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 8, 2025, with completion targeted for June 30, 2029. This award supports investigator-initiated biomedical research focused on elucidating the role of BRWD1-mediated cohesin conversion in B cell biology and function. The research examines how...
- Federal Project Grant Award Summary The University of Chicago received a $1.53 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 23, 2025, with completion targeted for June 30, 2030. The award funds mechanistic research investigating the role of regulatory T cells (Tregs) in acquiring and maintaining conventional T cell anergy to support transplantation tolerance. The...
- Federal Project Grant Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $451,000 Project Grant to the University of Chicago effective June 17, 2025, through May 31, 2027, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award funds investigator-initiated biomedical research focused on understanding how retroviruses, specifically Mouse Mammary Tumor Virus (MMTV), manipulate antibody responses and evade host protective immunity. The...
- Federal Project Grant Award Summary The University of Chicago received a $164,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 2, 2026, with completion by March 31, 2027. This award funds basic biomedical research aimed at dissecting the intrinsic role of SLC4A2 (anion exchanger 2, AE2), a membrane transporter protein, in the development of liver inflammation and...
- Federal Grant Award Summary The University of Chicago received a $243,824 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 19, 2026, with completion targeted for April 30, 2028. This research initiative investigates the mechanistic relationship between gut microbiome steroid hormone metabolism and inflammatory bowel disease (IBD) pathogenesis. The project delivers...
- Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded the University of Chicago a Project Grant of $109,076 on March 12, 2026, with a completion date of September 29, 2028. This award funds basic immunological research investigating the role of ETS1 (a transcription factor) in natural killer (NK) cell terminal maturation and function. NK cells represent critical immune effector...
- Federal Grant Award Summary The University of Chicago received a $442,296 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 9, 2026, with completion targeted for May 31, 2028. The award funds the development of a novel class of direct-acting antiviral therapeutics called RNA-degrading chimeras (RDCs) that selectively bind viral RNA and cleave it through general acid-general...
- Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Chicago a $451,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 5, 2026, with a completion date of January 31, 2028. The project focuses on identifying novel cellular targets to enhance targeted RNA degradation (TRD) technologies for antiviral drug development. Specifically, the research addresses current potency limitations of...
- Federal Project Grant Award Summary The University of California, San Diego received a $438,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 8, 2025, through June 30, 2027. The award supports basic immunological research focused on understanding the mechanisms that regulate immunoglobulin gene rearrangement, specifically investigating how enhancers and epigenetic...
Federal Project Grant Award Summary The University of Chicago received a $667,630 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2026, through June 30, 2031. The award funds research to decode the principles of gamma-delta T cell selection and functional maturation through investigation of IL17RA as a novel superantigen-like gamma-delta T cell receptor (GDTCR) ligand. The research aims to advance understanding of how endogenous ligands shape gamma-delta T cell repertoire, functional properties, and tissue localization—areas that remain poorly understood compared to conventional B cells and alpha-beta T cells. The project establishes screening pipelines to assess GDTCR reactivities and leverages complementary DNA library screening methodologies to identify and characterize molecular interactions, with particular focus on IL17 receptor A's role in accumulating and inducing effector programs in gamma-delta T cell populations. This five-year investigation delivers fundamental immunological research outputs that contribute to the broader NIAID mission of supporting biomedical research on infectious, immunologic, and allergic diseases. The research directly addresses knowledge gaps in adaptive immune system biology and may yield insights applicable to immune-mediated disease pathogenesis and therapeutic development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $667.6k | 7/1/26 |