Project Grant R21AI196149
- Federal Grant Award Summary The University of Chicago received a $108,512 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 25, 2025, with a completion date of March 31, 2029. This award funds research to define the immunological mechanisms driving the differentiation and functional potential of memory-phenotype CD8+ T cells (CD8-MP cells) in both infection and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Chicago a $807,799 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 15, 2025, with a completion date of June 30, 2030. This award supports fundamental immunological research investigating B cell-dependent regulatory T (Treg) cells and their role in controlling self-reactive B cells and autoantibody production. The research...
- Federal Project Grant Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $451,000 Project Grant to the University of Chicago effective June 17, 2025, through May 31, 2027, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award funds investigator-initiated biomedical research focused on understanding how retroviruses, specifically Mouse Mammary Tumor Virus (MMTV), manipulate antibody responses and evade host protective immunity. The...
- Federal Project Grant Award Summary The University of Chicago received a $3.02 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 8, 2025, with a completion date of June 30, 2029. This research project investigates the role of BRWD1-mediated cohesin conversion in B cell biology, specifically examining how this epigenetic mechanism coordinates genomic diversity with...
- Federal Grant Award Summary The University of Chicago received a $126,435 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 16, 2025 through August 31, 2030. This award supports a patient-oriented research program titled "INFOHIV: Clinical Informatics for Optimizing HIV Prevention and Care," which focuses on developing and implementing clinical informatics...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $109,076.00 to the University of Chicago under the Allergy and Infectious Diseases Research program (CFDA 93.855) on March 12, 2026, with completion targeted for September 29, 2028. This Project Grant supports investigator-initiated basic science research designed to elucidate the mechanistic role of ETS1, a transcription factor, in natural killer (NK) cell terminal maturation and function. NK...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $627,462 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 7, 2025, with completion scheduled for July 31, 2030. This research initiative focuses on understanding T cell exhaustion mechanisms in chronic viral infections and identifying therapeutic intervention strategies. The funded...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Chicago a $766,265 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 23, 2025, with a completion date of June 30, 2030. This research project investigates the role of regulatory T cells (Tregs) in acquiring and maintaining conventional T cell (Tconv) anergy in transplantation tolerance. The research builds upon preliminary...
- Federal Project Grant Award Summary Loyola University of Chicago's Health Sciences Campus received a $781,718 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 1, 2025 through May 31, 2030. The award supports the development of a novel T cell-based vaccine designed to prevent dengue virus (DENV) and Zika virus (ZIKV) infection while avoiding antibody-dependent enhancement...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Southern California $831,235 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 21, 2025, with a completion date of July 31, 2030. This Project Grant supports research to develop a broad-spectrum antiviral therapy by targeting a key nucleotide synthesis enzyme that diverse viruses—including SARS-CoV-2, Herpes Simplex Virus 1 (HSV-1),...
The University of Chicago received a $451,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 5, 2026, with a completion date of January 31, 2028. This award funds research to identify novel cellular targets for enhancing targeted RNA degradation (TRD) technologies in antiviral drug discovery. The project addresses a critical limitation in current TRD mechanisms, such as ribonuclease-targeting chimeras (RibotACs), which exhibit insufficient cellular potency despite showing promise in cell-free assays. The research deliverables encompass two primary aims. Aim 1 delivers identification of cellular determinants that inhibit RibotAC activity through genome-wide CRISPR knockout screening, with findings intended to significantly enhance the efficacy of existing RNA-degrading therapeutics targeting viral pathogens such as SARS-CoV-2. Aim 2 delivers discovery of novel cellular targets for TRD mechanisms through comprehensive genome-wide screenings utilizing a human genome plasmid library containing approximately 14,000 open reading frames. These research outputs are designed to advance antiviral drug development by overcoming potency limitations in current RNA degradation-based therapeutic approaches, ultimately contributing to improved treatment options for infectious diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 2/5/26 |