The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $192,260 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Rector & Visitors of the University of Virginia (UVA), beginning on March 1, 2025 and ending on February 28, 2030.
The grant supports research to characterize the systemic and mucosal immune response to adenovirus 40/41 infection in Bangladeshi children, and determine the efficacy of breast milk antibodies in providing passive immunity. Specifically, the research aims to: 1) describe the antibody repertoire to adenovirus 40/41 in the breast milk of Bangladeshi mothers and its association with infant infection, and 2) characterize the antibody responses to adenovirus 40/41 infection in Bangladeshi children and test for their association with subsequent infection using longitudinal serum and stool samples. This work is expected to advance the understanding of humoral immunity and infection dynamics for this major cause of childhood diarrheal illness in low- and middle-income countries.
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