Project Grant R01AI187023
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $318,085 to support research on the role of antibodies in controlling virus infections through Fc-dependent mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The research aims to elucidate the...
- This $451,000.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program, supports research to investigate the manipulation of antibody responses by a retrovirus. The research aims to enhance understanding of how pathogens can directly or indirectly modulate B cells, which play a critical role in providing long-term protective immunity. Specifically, the study will examine...
- This Project Grant award, valued at $416,276.00 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to investigate factors that modulate the Fc-mediated immune responses of antibodies. The research seeks to increase the potency of protection resulting from antibodies requiring Fc functions for influenza virus or antibodies against Streptococcus pneumoniae. The University...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $136,988 to the University of Maryland, Baltimore to conduct research on the mechanisms by which the transcription factor TFEB regulates autophagy (the cellular degradation process) during infection by Enterovirus D68 (EV-D68). The research aims to enhance understanding of viral manipulation of autophagy and...
- The University of Maryland, Baltimore received a $427,625 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to study CD27-mediated immune suppression by hematopoietic stem and progenitor cells (HSPCs), innate immune cells, or non-hematopoietic cells. The research aims to understand how the CD27-CD70 pathway regulates HSPC differentiation and function, and its potential role in modulating allogeneic T cell...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $743,752 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Utah. The grant will support research to define how chronic antigen stimulation contributes to epigenetic programming that drives dysfunction in virus-specific CD4+ T cells during chronic viral infection. The project aims to use highly innovative in vivo models and whole genome DNA methylation sequencing...
- This Project Grant award of $156,080 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The award supports research to uncover the underlying biology and key properties that define "broadly neutralizing" antibodies - those that can recognize and neutralize a wide range of related pathogens. Using SARS-CoV-2 as a model, the research aims to determine whether the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $238,972 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Research Foundation for the State University of New York, doing business as Sponsored Projects Services, to study the role of the cellular protein EHD4 in restricting HIV-1 infection. The research aims to determine the mechanism by which EHD4 decreases the infectivity of HIV-1 particles by impacting the incorporation of...
- The University of Maryland, College Park received a $423,803 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on defining the STING protein interactions required for rhinovirus replication. The project aims to investigate how the STING protein traffics to viral replication organelles and influences lipid metabolism pathways to promote rhinovirus infection. The award period is from July 15,...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,047,991 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Rector & Visitors of the University of Virginia. The grant, awarded on September 12, 2025, will fund research to investigate the molecular basis for paired receptor signaling in antiviral natural killer (NK) cells during murine cytomegalovirus (MCMV) infection. The research aims to delineate how NK cell receptor...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research grant program (CFDA 93.855), provides $463,676 to the University of Maryland, Baltimore for research to enhance the understanding of Fc-mediated effector functions in the context of infectious diseases. The project aims to dissect the mechanisms underpinning Fc-mediated effector functions, with a focus on antibody interactions with a viral surface protein, in order to develop new antibody-based preventions and therapies. The award period runs from Aug 7, 2025 to Jul 31, 2030. The research outcomes are expected to provide insights on how the immune system protects against infections and maintains immune balance to prevent autoimmune diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $463.7k | 8/7/25 |