This federal Project Grant award, valued at $188,980.00 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to elucidate the role of intestinal M cells in Rotavirus (RV) enteric infection, systemic dissemination, and pathogenesis. The award recipient, The Washington University in St. Louis, Missouri, will conduct research to determine the extraintestinal tissues and cell types targeted by...
The Washington University in St. Louis was awarded a 5-year, $668,488 Project Grant (R01AI188179) by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project aims to investigate the mechanisms by which the rotavirus outer capsid protein VP4 co-opts the host cell's actin-related protein 2/3 (Arp2/3) complex to enable cell-to-cell transmission of rotavirus, a leading cause of severe childhood diarrhea...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $516,900 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Immport Therapeutics Inc. (doing business as Antigen Discovery Inc.) to conduct research on humoral immunity to enteric viruses among infants and mothers in Bangladesh. The primary goal is to discover specific antibody correlates of protection from infant viral diarrhea caused by five major enteric human viruses: adenovirus, astrovirus,...
This federal Project Grant award of $659,313 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on investigating the influence of hypoxia (low oxygen conditions) on the antiviral functions of human intestinal epithelial cells. The research aims to understand how the oxygen gradient present in the gut microenvironment, with hypoxic conditions at the villus tips, impacts the innate immune...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $303,076.00 to the University of Washington to study how viruses evade the body's innate immune defenses. The funded research will determine the structural and biochemical properties of antimicrobial defensin peptides that enable their activity against viruses like adenovirus, rotavirus, and human papillomavirus. The...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $318,085 to support research on the role of cell, antigen, and antibody in controlling virus infection through Fc-dependent mechanisms. The research aims to understand the molecular determinants that govern how natural killer (NK) cells control virus dissemination through antibody-dependent cellular...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $721,555 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of viral transduction in the spread of pathogenic traits within intestinal microbiomes. The project, titled "DNA Transduction in Intestinal Microbiomes and the Spread of Pathogenicity Traits," aims to develop high-throughput methods to measure and identify transduction events that...
This $682,008 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to advance the development of monoclonal antibody (mAb) therapeutics for the treatment of paramyxovirus infections, with a focus on parainfluenza virus (PIV). The key objectives are to: 1) Define the human B cell repertoire response to the PIV fusion (F) and hemagglutinin-neuraminidase (HN) surface proteins; 2)...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $416,276 to the University of Georgia Research Foundation to investigate factors that modulate antibody-mediated immune responses. The goal is to identify optimal combinations of factors, such as epitope location, antibody glycosylation, and immune cell properties, that can enhance the protective capacity of antibodies...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $233,528 to support a research project to analyze the transcriptomic responses in human peripheral blood and stool following controlled infection with norovirus. The goal is to delineate the innate immune response to norovirus and identify transcriptional signatures that predict the development of effective...