Project Grant F32AI178920

Award Date 11/5/24
Completion Date 6/30/26
Dollars Obligated $149K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Seattle, WA 98109, USA
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  1. Determine the structural and biochemical properties of defensins essential for their antiviral activity against human adenovirus, rotavirus, and human papillomavirus.

  2. Elucidate the drivers of viral resistance to defensins by studying how defensin sensitivity relates to enterovirus transmission.

  3. Uncover the cellular mechanisms by which enteroviruses are neutralized by defensins and how they escape defensin action.

This work will provide insight into how viral pathogens bypass the host innate immune system and inform new approaches for antiviral development. The project will be conducted at the University of Washington from the award start date of November 5, 2024 through the ultimate completion date of June 30, 2026.

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