The federal Project Grant award, totaling $188,980 and awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports research to elucidate the role of intestinal M cells in Rotavirus (RV) enteric infection, systemic dissemination, and pathogenesis. The key objectives of the research project are to determine the extraintestinal tissues and cell types targeted by RV following oral inoculation, and to investigate the role...
This Federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to elucidate the mechanism by which intestinal helminth infections can promote viral infections, such as enteric adenoviral infection, independent of the classic type 2 immune response. The $981,781 award, with a performance period from May 2024 to March 2026, will allow researchers at the...
This $218,900 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the proteolytic determinants of flavivirus infection. The research aims to investigate the molecular factors that influence the cleavage activity of the flavivirus NS2B3 protease complex, which is essential for viral polyprotein processing and lifecycle. Specifically, the project will...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $146,922 to Emory University to study factors that influence the efficiency of influenza A virus (IAV) infection. The key research objectives are to: 1) examine the relationship between the intensity of exposure and diversity of viral barcodes under different modes of IAV exposure (direct contact, aerosol); and 2)...
This Federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $148,568 to support research on how viruses evade the body's innate immune defenses. The primary goal is to determine the molecular, cellular, and evolutionary mechanisms by which viruses, including adenovirus, rotavirus, and human papillomavirus, can resist or co-opt the antimicrobial activity of defensin...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA Program 93.855 (Allergy and Infectious Diseases Research), supports research focused on understanding the role of intestinal microfold (M) cells in creating an environment that fosters HIV persistence and reactivation. The $1,658,792 award, with a performance period from May 2024 to April 2025, will investigate whether the interaction between M cells and CD4+ T cells...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to investigate the role of the intestinal microbiota and the pattern recognition receptor NOD2 in enhancing pathogenesis of Coxsackievirus B3 (CVB3) infection. The $226,641 award, with a project period from December 5, 2024 to November 30, 2026, will enable the University of Colorado-Denver to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $632,585.00 to the University of Florida to elucidate the differences in innate and adaptive immune mechanisms during viral myocarditis between pediatric and adult populations. The research aims to investigate the role of sex, age, and hormone status in these differences. The award has a period of performance from July...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $668,488 to The Washington University in St. Louis to investigate the role of the actin-related protein 2/3 (Arp2/3) complex in enabling cell-to-cell transmission of rotavirus (RV) infections. The research aims to determine the biochemical and spatial interactions between the RV VP4 protein and the Arp2/3 complex, as...
The $233,528 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to conduct a comprehensive analysis of the immune responses to norovirus infection in a human challenge model. The project will profile the transcriptomic, cytokine, and innate immune cell responses in peripheral blood and stool samples collected from volunteers before and at multiple timepoints after...