Project Grant R01AI189249
Award Date
11/18/24
Completion Date
10/31/29
Dollars Obligated
$617K
Federal Agency
National Institute of Allergy and Infectious Diseases
Awardee
Emory University (S352L5PJLMP8)
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30322, USA
Similar Awards
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Program (CFDA 93.855), provides $653,693 to Emory University to conduct research on the structural details of HIV-1 virion assembly, maturation, and entry. The work will leverage cryo-electron microscopy and tomography to interrogate the molecular determinants and cellular interactions involved in the HIV-1 capsid lattice formation and...
This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the dynamics and evolution of HIV Gag and GagPol processing. The $752,745 award aims to use molecular dynamics simulations, single-molecule FRET imaging, and cryo-electron tomography to probe the structure and dynamics of Gag and GagPol that enable ordered processing by the viral...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $859,992 to Yale University to conduct research on the molecular mechanisms underlying HIV-1 maturation and the impact of capsid inhibitors on this process. The research aims to: 1) determine the high-resolution structural pathway of HIV-1 Gag assemblies and capsid during maturation within their native...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $220,224 to the University of Chicago to computationally investigate key morphological transitions in the HIV-1 life cycle. The research aims to gain a deeper mechanistic understanding of HIV assembly, maturation, and uncoating processes, with a focus on the roles of viral RNA, host cell factors, and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $194,616 to Emory University to develop virus-like particles (VLPs) for use in HIV-1 cure strategies. The key products and services to be delivered under this 18-month project include: Using VLPs to deliver the HIV-1 Tat protein as a latency reversing agent, as part of a "shock and kill" strategy to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on determining the mechanism by which the cellular protein EHD4 decreases the infectivity of HIV-1 virus particles. The $238,972 award to The Research Foundation For The State University Of New York (RF SUNY) aims to: 1) Characterize how EHD4 blocks the incorporation of HIV-1 envelope glycoproteins GP41 and GP120...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,332,155 to Emory University to conduct research focused on developing immunotherapies to cure HIV in SHIV-infected infant macaques. The key objectives are to evaluate strategies that leverage broadly neutralizing antibodies (bNAbs) in combination with virus reactivation, innate immune stimulation, and attachment...
This Project Grant award of $1,454,386.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports fundamental research to better understand the epigenetic regulation of the HIV-1 viral RNA cap. The research aims to define the structural basis of HIV cap hypermethylation and its linkage to modulating host innate immune signaling, with the goal of developing new treatments to neutralize deleterious...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $223,300.00 to Emory University to develop novel HIV capsid-targeting antivirals that can maintain activity against lenacapavir-resistant viruses. The research aims to synthesize and characterize analogs of lead compounds that can bind the HIV capsid protein and target clinically-relevant mutations conferring...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $132,300.00 to the Regents of the University of Michigan to conduct research on the multifaceted roles of phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] in HIV-1 assembly. The key research objectives are to: Elucidate the interplay between Gag multimerization and PI(4,5)P2 enrichment at HIV-1 assembly sites, and...