Project Grant R01AI188464

Award Date 7/22/25
Completion Date 6/30/30
Dollars Obligated $687K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Washington, USA
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This $427,627 federal Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate how gamma herpesvirus infection impacts key pathogenic interactions between B cells and CD4 T cells in a mouse model of multiple sclerosis (MS). The research aims to determine how viral infection affects B cells' support of disease-driving CD4 T cells, and how this impacts B cell-dependent versus B...
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This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $687,422 to the Benaroya Research Institute at Virginia Mason to conduct research focused on CD4+ tissue resident memory T cells and their role in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). The key objectives are to: 1) characterize the diversity and specialization of CD4+ tissue resident memory T cells during EAE, 2) determine the mechanisms that promote their maintenance in the central nervous system, and 3) explore methods to disrupt their tissue resident program and neutralize or eliminate them. This research aims to advance the understanding of how tissue resident memory T cells sustain autoimmunity, which could lead to the development of novel therapies for MS and other central nervous system autoimmune diseases. The award period is from July 22, 2025 to June 30, 2030.

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