This Project Grant award of $158,260 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate the role of enteric glial cells (EGCs) in the autoimmune disorder multiple sclerosis (MS). The award recipient, the Rector & Visitors of the University of Virginia, will conduct experiments to characterize T cell responses against EGCs in an experimental autoimmune encephalomyelitis (EAE) model, as well...
This $427,627 federal Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate how gamma herpesvirus infection impacts key pathogenic interactions between B cells and CD4 T cells in a mouse model of multiple sclerosis (MS). The research aims to determine how viral infection affects B cells' support of disease-driving CD4 T cells, and how this impacts B cell-dependent versus B...
This Project Grant award of $790,222 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) supports research by the Van Andel Research Institute (VAI) to investigate how the enzyme methionine adenosyltransferase 2A (MAT2A) regulates the differentiation and function of pathogenic T helper (Th) cells versus protective regulatory T (Treg) cells in the context of central nervous system autoimmunity, such as...
This $1,559,700 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) funds research by the Benaroya Research Institute at Virginia Mason (BRI) to investigate how genetic and epigenetic factors influence T cell function in autoimmune diseases. The key objectives are to: 1) use CRISPR-interference screening to identify regulatory regions that impact T cell proliferation and migration, 2) apply single-cell...
This Project Grant award of $305,000.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of stem-like T cells in multiple sclerosis (MS) disease progression. The key objectives are to: Rigorously test the hypothesis that a continuing stemness and differentiation of CD4+ T stem cells results in functional and transcriptomic diversification under evolving...
This Project Grant award, totaling $744,977.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research at Emory University to explore the role of T cells in providing protection against respiratory virus transmission. Key objectives include defining the cellular interactions and molecular mechanisms of tissue-resident memory T cells (TRM) that can limit the spread of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is supporting research to investigate the role of T cells in promoting post-acute memory deficits after COVID-19 infection in mice. The $107,995 award to The Washington University, which runs from July 2025 to June 2027, will fund a study to determine how pathogenic CD4+ T cells are recruited to the central nervous...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research conducted by the Scripps Research Institute to identify small molecule compounds that can selectively induce the differentiation of functional regulatory T cells (Tregs). The $417,984 award, effective March 7, 2025 through February 28, 2026, aims to: 1) determine the mechanism of action and optimize the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,863,501.00 over a 4-year period starting August 1, 2025 to conduct research on the mechanisms of CD4 T cell help to myeloid cells in tuberculosis (TB). The research aims to define how CD4 T cells, through direct cell-cell contact and indirect pathways, activate myeloid cells to control intracellular Mycobacterium...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $640,735.00 to Emory University to conduct research on understanding the mechanisms of CD8+ tissue-resident memory T cells (TRM) that mediate protection against respiratory virus transmission. The research aims to investigate the characteristics, durability, and molecular mechanisms of respiratory tract TRM...