This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $2,832,747 to the University of California, Irvine (UCI) to conduct research on the role of the SAPS3 protein in regulating T cell immunity during chronic viral infections. The key research objectives are to: 1) Determine the impact of SAPS3 on virus-specific T cells during acute and chronic viral infection, 2) Elucidate the molecular mechanisms by which SAPS3 regulates T cell activation, and 3) Evaluate the therapeutic potential of combining SAPS3 deletion and immune checkpoint blockade in cancer treatment. This 4-year award, starting on July 14, 2025, aims to provide a mechanistic understanding of how metabolic regulators function in T cells, with the goal of developing new immunotherapies for chronic infections, cancer, and autoimmune diseases.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.8m | 7/14/25 |