This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,269,762 to Northwestern University to develop a new microfluidic platform technology called SECRE (Secretion-Enabled Cell Ranking and Enrichment). The goal is to leverage this platform for high-performance sorting of immune cells based on their distinct secretion patterns, which will enable the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $2,419,181 in funding to Emory University to conduct research on enhancing T cell responses during chronic viral infections. The key objectives are to: Determine the role of inhibitory molecules expressed by virus-specific "stem-like" CD8 T cells in regulating their quiescence and effector cell output....
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $220,224 to the University of Chicago to computationally investigate key morphological transitions in the HIV-1 life cycle. The research aims to deepen the mechanistic understanding of HIV-1 assembly, maturation, and uncoating processes, which are critical for viral infectivity and inform the design of future...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $606,501.00 to Northwestern University to conduct research aimed at elucidating the regulatory role of the BRG1/BRM-associated factor (BAF) chromatin remodeling complex in germinal center (GC) B cell responses. The research will: 1) Investigate the epigenetic control of GC B cell differentiation by the...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), totaling $666,567, supports research focused on understanding the transcriptional regulation of human natural killer (NK) cell function during viral infections. The research aims to identify the mechanisms by which the transcription factor MEF2C regulates human NK cell cytotoxicity, proliferation, and antiviral cytokine...
This $2,535,942 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to study the viral and host determinants of donor-specific anti-HIV/SIV immunity mediated by APOBEC3 enzymes. The primary grantee, Texas Biomedical Research Institute, will integrate diverse viral and host datasets using computational and experimental techniques to identify the molecular determinants...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $775,986 to Northwestern University to conduct research aimed at identifying cellular and molecular targets to prevent cytomegalovirus (CMV) reactivation in kidney transplant recipients. The research will investigate the role of two key cellular stress response pathways, endoplasmic reticulum (ER) stress and...
This Project Grant award of $162,512 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to understand how pathogen exposure and inflammation impact the expansion and function of long-lived effector CD8 T cells in the memory compartment. The research aims to identify the cytokines and other factors that promote the formation and persistence of this critical T cell population, as well as determine how an...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $506,394.00 to the University of Chicago to conduct research on the mechanisms by which bacterial cholesterol-dependent cytolysins (CDCs) activate the NLRP3 inflammasome and stimulate immune responses. The research aims to define the specific motifs and host factors responsible for CDCs to reorganize host...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $160,000 to Northwestern University to develop an engineered cytokine platform that targets lipid-laden macrophages for local immunomodulation. The key products or services to be delivered include: Elucidating the molecular mechanisms by which the engineered cytokine construct (an IL-10 fusion protein that binds to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $189,713 to Northwestern University to conduct research on the role of the PIM1 kinase in regulating the metabolic adaptation of CD8 effector T cells during chronic viral infections. The research aims to elucidate the molecular mechanisms by which the IL-21-PIM1 signaling axis governs the metabolic properties and function of late-stage effector T cells, which are crucial for viral control in the chronic phase of infection. This grant, with an effective date of November 12, 2024, and an ultimate completion date of October 31, 2026, will support the university's investigations into this key aspect of the immune response to chronic viral diseases, a critical global health challenge.