Project Grant R01AI187253

Award Date 7/23/25
Completion Date 6/30/29
Dollars Obligated $3M
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Washington, DC, USA
Similar Awards
The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) was awarded a $677,325 federal Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) from the National Institute of Allergy and Infectious Diseases (NIAID). The 5-year grant, effective from August 1, 2025 to July 31, 2030, will support research to understand the mechanisms by which the bacterium Staphylococcus aureus utilizes exogenous fatty acids. The key objectives include: Elucidating...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $267,310 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Illinois in Chicago. The grant, awarded on August 27, 2024, supports research to evaluate the role of a lipoic acid transfer protein in Staphylococcus aureus metabolism and virulence. The project aims to determine how this lipoic acid transfer protein interfaces with other metabolic enzymes to control...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $560,178 Project Grant to the University of Wisconsin - Madison. The goal of this 5-year grant, which runs from Jul 25, 2025 to Jun 30, 2030, is to understand the dynamics of the interaction between Staphylococcus aureus bacteriophages, the bacteria, and the mammalian host. Specifically, the research aims to elucidate the...
This Project Grant award of $2,841,668.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research focused on understanding how the bacterial enzyme SagB in Staphylococcus aureus (S. aureus) modulates the host immune response and promotes infection. The key goals are to determine how SagB-modified peptidoglycan is recognized by immune cells, investigate the mechanism of SagB-dependent IL-1β...
This federal Project Grant award of $2,976,652 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to explore polyamine toxicity and resistance in epidemic bacterial skin pathogens, specifically methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes (Group A Streptococcus). The research aims to understand how polyamines enter and kill these bacteria, and how...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to develop real-time detection methods for Staphylococcus aureus transmission in hospital settings. The $3,210,845 award to New York University aims to integrate whole-genome sequencing with weekly colonization sampling to analyze transmission dynamics and create predictive models that can...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $231,700 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Texas A&M University System Health Science Center to develop novel biologics for treating Staphylococcus aureus (S. aureus) infections, including antibiotic-resistant strains like methicillin-resistant S. aureus (MRSA). The research aims to characterize the binding and neutralization properties of engineered DARPin proteins against...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Program (CFDA 93.855), provides $480,522 to the University of South Florida to conduct research on the role and regulation of secreted proteases in Staphylococcus aureus infections. The key objectives of this 5-year project are to: 1) Investigate the regulation of S. aureus secreted proteases, including the impact of a novel regulatory RNA...
This $488,783 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) federal grant program, will fund a 5-year research program at Stanford University to decode the cell surface chemistry and function of the pathogenic bacterium Staphylococcus aureus. The program involves three synergistic projects that will use an integrated experimental platform to illuminate and quantify key molecules, bonds, and...
This federal Project Grant award, valued at $312,000.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award will support research conducted by the University of Texas Health Science Center at Houston (UTHealth) to develop a single-cell resolution understanding of pathogenesis and antibiotic tolerance in Staphylococcus aureus infections. The research aims to explore the...

This $3,021,822 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research by Georgetown University to investigate the role of branched-chain fatty acids in the physiology and virulence of Staphylococcus aureus, a leading cause of skin and soft tissue infections. The research aims to: 1) determine the pathway by which S. aureus salvages and synthesizes branched-chain fatty acids from the metabolic byproducts of co-infecting bacteria like Enterococcus faecalis, and 2) understand how these fatty acids promote signaling through the S. aureus virulence regulator SAE to increase pathogenicity. The project will use genetic, biochemical, and lipidomics approaches, as well as in vitro and in vivo models, to elucidate these mechanisms, with the goal of informing the development of novel therapeutics to combat polymicrobial infections.

Generated 8/5/25, 5:24 AM