The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $560,178 Project Grant to the University of Wisconsin - Madison. The goal of this 5-year grant, which runs from Jul 25, 2025 to Jun 30, 2030, is to understand the dynamics of the interaction between Staphylococcus aureus bacteriophages, the bacteria, and the mammalian host. Specifically, the research aims to elucidate the mechanisms by which the FSA3 prophage acts as a regulatory switch controlling the production of the S. aureus beta-toxin, a virulence factor that can increase the severity of infections like pneumonia and infective endocarditis. The research will investigate the temporal dynamics of prophage excision and integration, the regulatory networks governing beta-toxin expression, and the molecular responses driven by the beta-toxin's sphingomyelinase activity, with the goal of providing critical insights into S. aureus host adaptation and pathogenesis.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $560.2k | 7/23/25 |