Project Grant R01AI186276

Award Date 8/1/25
Completion Date 7/31/30
Dollars Obligated $677K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Kansas City, KS 66160, USA
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The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $267,310 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Illinois in Chicago. The grant, awarded on August 27, 2024, supports research to evaluate the role of a lipoic acid transfer protein in Staphylococcus aureus metabolism and virulence. The project aims to determine how this lipoic acid transfer protein interfaces with other metabolic enzymes to control...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $560,178 Project Grant to the University of Wisconsin - Madison. The goal of this 5-year grant, which runs from Jul 25, 2025 to Jun 30, 2030, is to understand the dynamics of the interaction between Staphylococcus aureus bacteriophages, the bacteria, and the mammalian host. Specifically, the research aims to elucidate the...
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The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) was awarded a $677,325 federal Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) from the National Institute of Allergy and Infectious Diseases (NIAID). The 5-year grant, effective from August 1, 2025 to July 31, 2030, will support research to understand the mechanisms by which the bacterium Staphylococcus aureus utilizes exogenous fatty acids. The key objectives include:

  1. Elucidating the regulation and metabolic potential of S. aureus' fatty acid degradation pathway.
  2. Investigating the biochemical and structural details of the FakAB system that allows S. aureus to incorporate external fatty acids directly into its lipids.
  3. Determining how S. aureus transcriptionally responds to fatty acids as environmental signals versus perturbations to cellular metabolism.

This comprehensive research project aims to provide critical insights into the fundamental biology and pathogenic strategies of S. aureus, a major human pathogen responsible for a range of serious infections.

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