The University of Utah received a $3,078,308 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The grant, awarded on August 1, 2025, supports research to determine the TCR-dependent and epigenetic mechanisms that drive secondary CD4+ T cell responses to influenza infection. The project aims to: 1) Examine the relationship between TCR signal strength, TCR...
This Project Grant award, valued at $735,078, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The funding supports a 5-year research project to investigate the molecular mechanisms of innate immune memory in humans, with a focus on understanding the epigenetic determinants that enable long-lasting "trained immunity" in myeloid and lymphoid progenitor cells. The...
The federal Project Grant award R01AI192874 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $649,530 award supports research to understand how B cells and their antibody receptors can contribute to protection from or susceptibility to dengue virus infection and disease progression. The project aims to define the mechanistic requirements underpinning B cell receptor-dependent...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $806,693.00 to New York University (NYU) from June 12, 2025 to May 31, 2030. The grant supports research to elucidate the mechanisms governing lymphangiogenesis (growth of lymphatic vessels) in acute and homeostatic inflammation, and to determine the functional consequences of lymphatic encapsulation of B...
The University of Florida was awarded a $530,791 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, titled "METABOLIC ENFORCEMENT OF SELECTION IN ANTI-DNA B CELLS VS. ANTIGEN-SPECIFIC B CELLS", will fund research to investigate the mechanisms that distinguish the selection and survival of foreign-antigen specific B cells versus autoreactive B cells. Specifically, the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA Program 93.855 Allergy and Infectious Diseases Research, is funding a $556,843 research initiative at the University of Pittsburgh to investigate the development and regulation of the extrafollicular B cell response. The key objectives are to: Examine the role of B cells in enhancing the extrafollicular response and test the self-renewal capacity of the extrafollicular B cell population....
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,018,216 to the University of Chicago to conduct research on the contributions of BRWD1-mediated cohesin conversion to B cell biology. The research aims to define BRWD1 functions in germinal centers, determine the mechanisms and importance of BRWD1-mediated GAGA motif recognition, and understand how BRWD1 and cohesin...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) provides $1,172,336.00 to the University of Massachusetts Medical School over a 5-year period starting on August 19, 2024. The goal of the research is to investigate how distinct age-associated B cell subsets can protect the aged from influenza. Specifically, the project will determine the potential of different...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $416,276 to the University of Georgia Research Foundation, Inc. to conduct research aimed at increasing the protective capacity of antibodies by enhancing Fc-mediated immune responses. The key objectives are to: 1) quantify how factors such as epitope location, antibody glycosylation, and...
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine the role of B cell-dependent regulatory T cells in maintaining B cell tolerance and preventing autoimmunity. The $807,799 award to the University of Chicago aims to identify B cell-dependent regulatory T cell clones, define their developmental requirements and functions, and determine the...