This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine the role of B cell-dependent regulatory T cells in maintaining B cell tolerance and preventing autoimmunity. The $807,799 award to the University of Chicago aims to identify B cell-dependent regulatory T cell clones, define their developmental requirements and functions, and determine the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 2-year Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) worth $162,000 to The Johns Hopkins University to study how atypical B cells can be used to enhance vaccine responses in immunosuppressed individuals. The research project aims to define populations of immunosuppressed individuals who utilize these atypical CD11c+ B cells, assess their interaction with T cells, and target fatty acid oxidation...
This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to determine how germinal center (GC) responses are controlled in health and how governance loss promotes immune deficiencies and autoimmune diseases. The key objectives are to establish the lineage and functional differences between induced T follicular regulatory (iTFR) and natural TFR (nTFR) cells, and assess...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $379,609 to the University of Pittsburgh to investigate B cell tolerance to commensal antigens. The research aims to: 1) Define contexts in which B cell tolerance to commensal antigens is perturbed, 2) Isolate specific commensal bacteria that interact with LPS-specific B cell receptors to further understand tolerance...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,018,216 to the University of Chicago to conduct research on the contributions of BRWD1-mediated cohesin conversion to B cell biology. The research aims to define BRWD1 functions in germinal centers, determine the mechanisms and importance of BRWD1-mediated GAGA motif recognition, and understand how BRWD1 and cohesin...
This $107,948 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 (Allergy and Infectious Diseases Research) supports the University of Southern California (USC) in engineering B cells for enhanced HIV control. The key objectives are to: 1) Design synthetic protein signaling molecules to engage B cell circuits induced by T helper cells, and screen their function in reporter cell lines; 2) Examine the ability of these molecules to drive B...
This $189,540 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research to understand the role of apolipoprotein E (APOE) in regulating lymph node stromal cell function and lipid metabolism during autoimmune disease. The research aims to determine how APOE inhibits the suppressive capacity of lymph node stromal cells, known as T cell zone fibroblastic reticular cells (TRCs), and how APOE...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $778,829.00 to Emory University to conduct research on early-life B-cell and plasma cell development in the human spleen. The 5-year project aims to characterize the mechanisms of adaptive immunity operating at birth, focusing on B-cell development, spontaneous differentiation of antibody-secreting cells, and the...
This Project Grant award of $1,083,816.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of Colorado-Denver to investigate the role of CD79A as a molecular switch regulating B cell activation and tolerance. The key objectives are to determine how individual CD79A immunoreceptor tyrosine-based activation motif (ITAM) tyrosines impact B cell receptor (BCR) signaling and downstream...
This federal Project Grant award of $183,701 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award will support a research project at the University of Pittsburgh titled "Identification of Post-Translationally Modified Antigens Using Genetic Code Expansion". The project aims to develop a scalable platform for presenting thousands of epitopes with precisely defined...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA Program 93.855 Allergy and Infectious Diseases Research, is funding a $556,843 research initiative at the University of Pittsburgh to investigate the development and regulation of the extrafollicular B cell response. The key objectives are to:
Examine the role of B cells in enhancing the extrafollicular response and test the self-renewal capacity of the extrafollicular B cell population.
Characterize the transcriptional and epigenetic profile of the continuously proliferating extrafollicular B cell population and investigate the effects of cytokines like IL-12 and IFNγ on this gene regulatory network.
Use spatial transcriptomics and genetic approaches to define the roles of dendritic cells, CD4 T cells, and CXCR3 in the extrafollicular B cell response niche.
This research aims to provide a significant conceptual advance in understanding the extrafollicular B cell response, a critical but understudied aspect of the adaptive immune system, with potential implications for treating autoimmune disorders and developing novel vaccine and cancer therapeutic strategies. The project will be conducted over a 5-year period from July 2025 to June 2030.