The University of Florida was awarded a $402,150 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The award, effective July 23, 2025 through June 30, 2027, supports research into the viral mechanisms by which Kaposi's sarcoma-associated herpesvirus (KSHV) engages host transcription factors to promote its lytic replication cycle. The project aims to uncover the protein...
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine the role of B cell-dependent regulatory T cells in maintaining B cell tolerance and preventing autoimmunity. The $807,799 award to the University of Chicago aims to identify B cell-dependent regulatory T cell clones, define their developmental requirements and functions, and determine the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $137,064 Project Grant under CFDA 93.855, Allergy and Infectious Diseases Research, to the University of Florida. The 2-year grant, with a period of performance from Jul 25, 2025 to Jun 30, 2027, will fund research to develop new conceptual frameworks for modeling and validating dynamic accessibility to healthcare using system science approaches. The research aims to address limitations in existing population-based and...
The federal Project Grant award R01AI192874 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $649,530 award supports research to understand how B cells and their antibody receptors can contribute to protection from or susceptibility to dengue virus infection and disease progression. The project aims to define the mechanistic requirements underpinning B cell receptor-dependent...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,018,216 to the University of Chicago to conduct research on the contributions of BRWD1-mediated cohesin conversion to B cell biology. The research aims to define BRWD1 functions in germinal centers, determine the mechanisms and importance of BRWD1-mediated GAGA motif recognition, and understand how BRWD1 and cohesin...
The federal Project Grant award R01AI186945 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) for $625,348 with a period of performance from Jul 3, 2025 to Jun 30, 2030. The grant supports research at the University of Utah to define the role of the NF-kB signaling network in regulating affinity maturation and the generation of plasma cells and memory B cells. The goal is to improve...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA Program 93.855 Allergy and Infectious Diseases Research, is funding a $556,843 research initiative at the University of Pittsburgh to investigate the development and regulation of the extrafollicular B cell response. The key objectives are to: Examine the role of B cells in enhancing the extrafollicular response and test the self-renewal capacity of the extrafollicular B cell population....
This federal Project Grant award for $246,623.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research at New York University School of Medicine to study the molecular control of tolerogenic dendritic cell function. The research aims to characterize the dendritic cell subset responsible for maintaining T cell tolerance, including investigating aberrant cytokine...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $150,921 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Rector & Visitors of the University of Virginia (UVA) to investigate the interplay between membrane rafts and biomolecular condensates in regulating T cell activation. The goal is to provide evidence and mechanistic insights on how these two cellular structures mutually regulate to tune T cell signaling, which can...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $415,978 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Central Florida. The grant aims to identify novel boron-based inhibitors of mycobacterial class II aminoacyl-tRNA synthetases, which are essential enzymes for protein synthesis in Mycobacterium tuberculosis (MTB). The research will use a high-throughput screening assay to test a library of boron-containing...