Project Grant R03AI185905

Award Date 7/25/25
Completion Date 6/30/27
Dollars Obligated $137K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Florida, USA
Similar Awards
The University of Florida was awarded a $402,150 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The award, effective July 23, 2025 through June 30, 2027, supports research into the viral mechanisms by which Kaposi's sarcoma-associated herpesvirus (KSHV) engages host transcription factors to promote its lytic replication cycle. The project aims to uncover the protein...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $422,125 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Florida. The grant will fund research to develop a Salmonella-based vaccine that can deliver Francisella type VI secretion system proteins as antigens to induce protective immunity against tularemia, a potentially deadly infectious disease. The research aims to leverage an established Salmonella antigen...
The University of Florida was awarded a $530,791 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, titled "METABOLIC ENFORCEMENT OF SELECTION IN ANTI-DNA B CELLS VS. ANTIGEN-SPECIFIC B CELLS", will fund research to investigate the mechanisms that distinguish the selection and survival of foreign-antigen specific B cells versus autoreactive B cells. Specifically, the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $184,375 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Florida International University (FIU) to optimize a novel antimicrobial peptide, A4-X7, for pulmonary delivery to combat antimicrobial-resistant respiratory infections. The funded research aims to prepare, characterize, and evaluate the antimicrobial and antibiofilm activities of the A4-X7 formulation for aerosolized...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $769,414 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Iowa. The grant, awarded on July 9, 2025, will support research investigating how the cellular protein SAMHD1 regulates innate immune responses and HIV-1 gene expression in macrophages. The research aims to define the mechanisms by which SAMHD1 suppresses type I interferon induction and NF-kB activation...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $367,332 to Florida State University (FSU) to develop and pilot a Youth Learning Health Community (Y-LHC) in North Florida. The project aims to optimize the implementation of evidence-based HIV prevention interventions tailored for youth through the integration of data science, implementation science, and community...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $415,978 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Central Florida. The grant aims to identify novel boron-based inhibitors of mycobacterial class II aminoacyl-tRNA synthetases, which are essential enzymes for protein synthesis in Mycobacterium tuberculosis (MTB). The research will use a high-throughput screening assay to test a library of boron-containing...
This Project Grant award of $537,861 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to extend statistical methods for analyzing infectious disease transmission dynamics. The key objectives are to: Develop efficient computational methods to incorporate pathogen genetic sequences into parameter estimation for pairwise survival analysis models, which can reduce bias and variance in...
This Project Grant award of $1,454,386.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports fundamental research to better understand the epigenetic regulation of the HIV-1 viral RNA cap. The research aims to define the structural basis of HIV cap hypermethylation and its linkage to modulating host innate immune signaling, with the goal of developing new treatments to neutralize deleterious...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA Program 93.855 - Allergy and Infectious Diseases Research, is providing $146,922.00 to Emory University to conduct research on factors that modulate the efficiency of influenza A virus (IAV) infection. The research aims to examine the relationship between the intensity of IAV exposure and infection diversity under distinct modes of exposure (intranasal vs. aerosol). Additionally, the...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $137,064 Project Grant under CFDA 93.855, Allergy and Infectious Diseases Research, to the University of Florida. The 2-year grant, with a period of performance from Jul 25, 2025 to Jun 30, 2027, will fund research to develop new conceptual frameworks for modeling and validating dynamic accessibility to healthcare using system science approaches. The research aims to address limitations in existing population-based and temporally static measures of healthcare accessibility by incorporating temporal variations, individual heterogeneity, and social interactions. The University of Florida will implement system dynamics and agent-based models to study healthcare accessibility in Florida in the context of the recent "tripledemic" (flu, RSV, and COVID-19) during the 2022-23 season, and attempt to validate the model results. The research seeks to provide researchers and policymakers with improved tools for monitoring healthcare accessibility dynamics and mitigating health disparities.

Generated 8/5/25, 3:42 AM