The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $426,648 Project Grant (R21AI180765) to the Dartmouth-Hitchcock Clinic to advance the research and development of antimicrobial photodynamic therapy for preventing infections in patients with osseointegrated prostheses. The project aims to develop novel treatments to reduce the risk of infections in these patients, a significant challenge in this medical field. As part of the grant, the Dartmouth-Hitchcock Clinic has...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $261,492 Project Grant (CFDA 93.855 Allergy and Infectious Diseases Research) to Tufts University School of Medicine to study the epigenetic regulation of sporulation in Clostridioides difficile, a major nosocomial pathogen. The project builds on previous research identifying a C. difficile-specific DNA methyltransferase (CamA) that enhances the bacterium's ability to form infectious spores and persist in mice. The...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $304,280 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Broad Institute, Inc. to conduct deep integration of multi-omics and patient health data to clarify risk factors of enterococcal infective endocarditis. The key objectives are to: 1) curate and assess patient health and demographic variables to detect characteristics associated with infective endocarditis; 2) perform...
This federal Project Grant award of $997,821.00, provided by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program, supports advanced biomedical research initiatives focused on transforming healthcare for military service members and the general public. The primary awardee, Trustees of Dartmouth College, will conduct research to investigate the pathogenic role of neutrophil subpopulations in lupus nephritis. The project includes sub-awards to The...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop a novel positron emission tomography (PET) imaging agent called [18F]fluoromannitol to diagnose osteomyelitis, a bacterial infection, in patients with sickle cell disease. The $894,735 award to St. Jude Children's Research Hospital will fund research to establish a streamlined radiosynthesis process, validate...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $442,024 to Trustees of Dartmouth College to elucidate the cellular mechanisms driving antibody effector functions. The research seeks to establish quantitative relationships between antigen, antibody, and effector biology in order to generate antibody design criteria that can predict and optimize...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,352,406.84 Project Grant (R01DE033175) to Trustees of Dartmouth College under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121). The project aims to develop a noninvasive ultrasound-based molecular imaging tool to identify micrometastases in the lymph nodes of head and neck cancer patients. The grant will fund the synthesis of targeted nanodroplet contrast agents and the application of...
This Project Grant award of $840,462.15 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to advance the understanding of Staphylococcus epidermidis biofilm formation on medically relevant surfaces. The primary objectives are to: Establish the structural and biophysical determinants that influence bacterial attachment and biofilm formation on polymethylmethacrylate (PMMA) surfaces, a material...
This $156,703 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to develop a novel photomedicine approach for diagnosing, monitoring, and treating polymicrobial infections in diabetic wounds. The research, conducted at Massachusetts General Hospital, aims to leverage a bacterial metabolite called glutamate 1-semialdehyde (GSA) that...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $300,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Baebies, Inc., a Durham, North Carolina-based company that specializes in advanced medical diagnostic equipment and devices. The purpose of this grant is to develop a rapid, point-of-care diagnostic test to identify viable sexually transmitted infections (STIs), reduce overtreatment, and prevent the emergence of...