Epigenetic regulation of sporulation in clostridioides difficile - clostridioides difficile is a major nosocomial pathogen that costs the US healthcare system ~$5 billion to treat each year

Active Project Grant Awarded Last action

Award ID
R21AI188339
Recipient
Awarding agency
Obligated
$465,446

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 91% complete
Place of performance
Boston, MA 02111, USA

Award details come from USAspending.gov.

Description

Since the cama DNA methyltransferase is important for infectious spore formation and persistence in mice, and cama is unique to c. Difficile, elucidating the impact of DNA methylation on c. Difficile physiology could facilitate the development of new therapeutics.

Transactions

Action Obligated Date
Amendment Epigenetic regulation of sporulation in clostridioides difficile - DNA methylation is a major mechanism for epigenetically regulating transcription in… $203,954
Original award $261,492

Subawards

Subrecipient Amount Awarded
Icahn School Of Medicine At Mount Sinai This project builds on a previous paper that we published with Dr. Aimee Shen’s lab at Tufts, in which we identified a Clostridioides difficile-specific… $67,766
Icahn School Of Medicine At Mount Sinai $69,361

Quick answers

Who received award R21AI188339?

R21AI188339 was awarded to Trustees Of Tufts College by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on January 28, 2025.

How much is award R21AI188339 worth?

$465,446 has been obligated on R21AI188339.

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