Project Grant R01AI188432
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $530,385.00 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct research on how host cell factors regulate the activity of the essential flaviviral enzyme NS3 in viral pathogens like dengue, Zika, and West Nile viruses. The research aims to define in detail how...
- This $254,250 Project Grant was awarded on July 1, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to understand how Chikungunya virus (CHIKV), a mosquito-borne human pathogen, infects microvascular endothelial cells, which play critical roles in vascular homeostasis and protecting against pathogens. The research aims to identify viral and host factors that restrict...
- This federal Project Grant award of $649,530.00, awarded on July 7, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of B cell receptor (BCR)-dependent infection as a mechanism of immune-mediated enhancement of Dengue virus (DENV) infection and pathogenesis. The funded research aims to explore how cross-reactive non-neutralizing antibodies, when expressed...
- This federal Project Grant award, with ID R21AI187731, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $245,895 award, granted on November 14, 2024, supports research at the Icahn School of Medicine at Mount Sinai to systematically assess the impact of ubiquitination on Flavivirus infection using CRISPR-Cas9 base editing approaches. The goal is to discover novel pathways that promote...
- This Project Grant award of $154,500 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to unravel the mechanisms behind Zika virus (ZIKV)-induced cardiac dysfunction in a mouse model. The overarching objective is to deepen the understanding of viral heart disease pathogenesis and identify novel therapeutic targets. The award will fund in vitro and in vivo investigations to explore the impact of...
- This $157,884 Project Grant, awarded on December 26, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the effects of a chromosomal inversion in the Anopheles coluzzii mosquito on gene regulation and its relationship to malaria resistance. The central hypothesis is that genetic variation between the inversion forms leads to differential enhancer activity and gene...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $738,880 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the Regents of the University of California at Riverside. The grant funding will support research to identify and characterize protective antibodies against Crimean-Congo Hemorrhagic Fever Virus (CCHFV), a potentially fatal virus that has been rapidly spreading across parts of Europe, Asia, and Africa. The...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $133,223 Project Grant to the University of Washington to characterize host proteins that restrict Zika virus (ZIKV). The project aims to identify host genes, including both interferon-stimulated genes and non-interferon-stimulated genes, that contribute to the innate immune system's ability to restrict ZIKV replication in human...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $423,125 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M University System Health Science Center. The grant, awarded on July 17, 2025, aims to develop an intein-based QF2 system for controllable protein expression in the nervous system of the Aedes aegypti mosquito. This research seeks to leverage genetic and synthetic biology tools to disrupt the propagation of...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $134,577 project grant to the University of California, Los Angeles (UCLA) on January 26, 2025. The grant supports research to elucidate the molecular mechanisms by which encephalitic alphaviruses, such as Sindbis and Chikungunya viruses, can cross the blood-brain barrier and invade the central nervous system. Utilizing a stem...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to decipher the role of the chemokine receptor CCR5 in protecting against flavivirus infections during pregnancy. The $3,021,038 grant, awarded on September 2, 2025, will fund a study to investigate the mechanisms by which CCR5 provides neuroprotection against West Nile virus, Zika virus, and other flaviviruses, and how the loss of CCR5 increases susceptibility to these viruses during maternal infections, leading to poor pregnancy outcomes like microcephaly and fetal loss. The research will be conducted by the Icahn School of Medicine at Mount Sinai, a prominent academic medical center and research institution in New York.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.0m | 9/2/25 |