This Project Grant award in the amount of $884,454 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research aimed at investigating the immunomodulatory effects of secondary bile acids produced by the gut bacterium [Ruminococcus] gnavus. The research team is engineering a two-strain bacterial consortium to toggle the production of the secondary bile acid isodeoxycholic...
This federal Project Grant award of $389,500.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award will fund research at the University of Chicago to study the role of alpha-defensins, a type of antimicrobial peptide, in regulating the gut microbiome and host responses to intestinal pathogens. The proposed research aims to use CRISPR/Cas9 gene editing and gnotobiotic (germ-free)...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $224,807 to the University of California, Irvine to identify and engineer microbial enzymes that can control peptidoglycan (PG) metabolite levels in the gut. The goal is to develop functionalized probiotics capable of selectively modulating circulating PG fragments, which have been shown to have wide-ranging effects on...
This $682,125 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to investigate the role of the human gut microbiome in protecting against Shigella infection. The project will characterize microbiome features associated with resistance to Shigella, use a novel mouse model to identify factors driving microbiome-mediated protection, and further study bacterial mechanisms...
This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to investigate how the human microbiome influences the immune system's response to sepsis. The $462,000 award will fund research conducted by the University of Rochester to determine the mechanisms by which the microbiome primes neutrophils, a key immune cell type, and how this impacts sepsis outcomes. The...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $364,324 to The Leland Stanford Junior University to study the regulatory role of microbially-derived metabolites on the host immune system, particularly the impact on macrophages. The research aims to determine the metabolic pathways responsible for producing immune-associated microbial...
This federal Project Grant award, totaling $438,608, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of this grant is to investigate the role of host genetics in shaping the intestinal Lactobacillus population using a murine model. Specifically, the research aims to determine the mechanisms by which host genetics directly influence the population of Lactobacillus murinus, a...
This federal Project Grant award of $827,922.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award will fund a research project at the University of California, San Diego that aims to elucidate new mechanisms of competition between the pathogen Salmonella enterica serovar Typhimurium (STM) and the gut microbiota. The project will utilize cutting-edge multi-omics approaches,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $195,213 to the University of California, Davis (UC Davis) to investigate the mechanisms by which the gut microbiota, specifically short-chain fatty acids, antagonize infection by the enteric pathogen Yersinia enterocolitica. The project aims to elucidate the mechanism of propionate-mediated toxicity against Y....
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 2-year, $171,254 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Nimml Institute Inc., a non-profit research organization in Blacksburg, Virginia. The grant supports research aimed at elucidating novel immunometabolic mechanisms that can intercept bacterial toxin internalization and processing to suppress cell damage caused by Clostridioides difficile infection (CDI). Specifically, the...