Project Grant R21AI182927

Award Date 12/1/24
Completion Date 11/30/26
Dollars Obligated $171K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Blacksburg, VA, USA
Similar Awards
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $521,030 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research on Clostridioides difficile, a leading cause of antibiotic-associated disease. The project aims to define the interplay between stochastic and regulatory mechanisms underlying the heterogeneous expression of C. difficile flagella and toxins, which are key...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $261,492 Project Grant (R21AI188339) to Tufts University School of Medicine to study the epigenetic regulation of sporulation in Clostridioides difficile, a major nosocomial pathogen that costs the U.S. healthcare system approximately $5 billion to treat annually. The research aims to identify specific methylation sites that mediate the epigenetic regulation of sporulation in C. difficile, as the CamA DNA...
This $502,500 project grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award will fund research to elucidate the molecular mechanisms underlying ferrosome organelle biogenesis in the bacterium Clostridioides difficile, which is a leading cause of antibiotic-associated intestinal infections. The research aims to define how the ferrosome system enables C. difficile to adapt to iron...
This $780,162 Project Grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research at Old Dominion University from August 2022 through July 2026 exploring the role of nutrient and stress sensing in regulating Clostridioides difficile physiology and behavior within the host. The research aims to determine how the stringent response regulates disease-relevant bacterial processes and characterize enzymes that mediate alarmone metabolism...
The federal Project Grant award R01AI178776 in the amount of $1,541,024.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Notre Dame DU Lac. The grant aims to elucidate the spore germination pathway of the bacterium Clostridioides difficile and develop pharmacological interventions to interrupt the recurrent cycle of C. difficile infection (CDI). Key objectives...
This $894,552 project grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at the University of Nevada, Las Vegas to probe the effect of a high-fat/high-protein diet on Clostridioides difficile infection. Specifically, the researchers will examine how such a diet impacts inflammation, intestinal permeability, and the gut microbiome before and after antibiotic...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $222,852 to support research into the regulation of virulence factors in the pathogenic bacterium Clostridioides difficile. The primary objective is to identify and annotate Rho, NusA, and NusG dependent transcriptional terminators in C. difficile to understand how these regulatory factors influence the...
The federal Project Grant award of $661,693 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand the structure and function of a new family of peptidoglycan crosslinking enzymes in the bacterium Clostridioides difficile. The key goals are to: (I) determine the structure and catalytic mechanism of the VanW domain of these enzymes, (II) examine how they are recruited to the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $152,656 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The grant, titled "Synaptopodin and Its Role in Shigella flexneri Intercellular Spread," will fund research to investigate the molecular mechanisms by which the protein synaptopodin promotes the ability of the Shigella bacteria to spread between cells, a critical process for...
This $226,641 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), to the University of Colorado-Denver. The project aims to examine the role of the intestinal protein NOD2 and the gut microbiota in enhancing pathogenesis of Coxsackievirus B3 (CVB3), a virus that can cause intestinal inflammation, pancreatitis, myocarditis, and central nervous system diseases. The researchers will...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $171,254 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Nimml Institute Inc., a non-profit research organization in Blacksburg, Virginia. The funding supports a 2-year research project to elucidate novel immunometabolic mechanisms that can intercept bacterial toxin internalization and processing to suppress cell damage caused by Clostridioides difficile infection (CDI). The research aims to investigate how immunometabolic pathways can modulate RhoA and Rac1 glucosylation by C. difficile toxins, as well as regulate endosomal pH and toxin translocation in colonic epithelial cells. The ultimate goal is to provide novel mechanistic insights that can guide the development of new host-based therapies to treat CDI and other toxin-producing bacterial infections.

Generated 7/8/25, 1:23 PM