Project Grant R21AI186034
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $844,975 to Northwestern University to conduct research on how the bacterial pathogen Salmonella Typhimurium makes rapid and accurate decisions to survive when engulfed by immune cells. The project aims to use quantitative approaches and live-cell imaging to track how Salmonella balances speed and accuracy in activating virulence genes to adapt to the intracellular environment of...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Leland Stanford Junior University a Project Grant of $771,210 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct biomedical research on Salmonella persistence mechanisms. The award, effective February 19, 2026, with a completion date of January 31, 2031, supports research investigating how Salmonella enterica serovar Typhimurium (STM) maintains persistent...
- This $914,479 Project Grant award from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) supports fundamental research into microbiome spatial organization and community assembly. The project, initiated September 1, 2025 and extending through July 31, 2028, is being conducted at Columbia University and will deliver a defined synthetic human gut microbiome (SYNHCOM) model system and associated research tools for...
- This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA Program 93.213 - Research and Training in Complementary and Integrative Health, provides $506,000.00 in funding to the Scripps Research Institute in La Jolla, CA from September 13, 2024 to August 31, 2026. The award supports research to develop orally available recombinant peptidoglycan hydrolase therapeutics that can promote intestinal barrier function and protect against enteric...
- NSF POSTDOCTORAL FELLOWSHIP IN BIOLOGY FY 2021: USING METACOMMUNITY THEORY TO ASSESS THE IMPACT OF MULTI-SPECIES INTERACTIONS ON GUT MICROBIAL ASSEMBLY This $138,000 Project Grant from the National Science Foundation Division of Environmental Biology will fund research from January 1, 2022 to December 31, 2023. The grant was awarded under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise...
- This $502,071 National Science Foundation project grant supports research at the University of California, Merced to define metabolic complementation within the sea anemone microbiome. The research aims to advance understanding of how microbial communities cooperate to enhance the fitness, health and survival of eukaryotic hosts. Specifically, the three-year award will fund work to quantify the microbiome's impact on host fitness using gnotobiotic sea anemones, reintroduce isolated microbial...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $131,076 Project Grant to The Leland Stanford Junior University under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 4, 2025, with completion targeted for July 31, 2027. This award supports biomedical research investigating the functional understanding of genotypic and phenotypic diversity across Salmonella species, a pathogen responsible for over 100...
- This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $426,425 to Baylor College of Medicine to conduct a pilot study examining the relationship between gut microbiome composition, metabolic dysfunction-associated steatotic liver disease (MASLD), and hepatocellular carcinoma (HCC). The key objectives of this 2-year study are to: 1) characterize baseline gut microbiome diversity associated with MASLD with and without HCC, 2)...
- The National Science Foundation awarded a two-year, $138,000 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to conduct research characterizing the genetic mechanisms of bacteria-phage coevolution in Listeria and Salmonella. The postdoctoral fellow will analyze the dynamic relationships between the foodborne pathogens Listeria monocytogenes and Salmonella enterica, and their bacteriophages. Through serial passaging experiments and whole genome sequencing, the...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $262,410 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded August 1, 2025, with completion expected July 31, 2027. This research project investigates how the commensal bacterium Turicibacter sanguinis modulates intestinal metabolites to reduce infection severity caused by the pathogenic bacterium...
APPLIED METATRANSCRIPTOMICS AND METATRANSLATOMICS TO IDENTIFY NEW MECHANISMS OF SALMONELLA-MICROBIOTA COMPETITION - SUMMARY THE PATHOGEN SALMONELLA ENTERICA SEROVAR TYPHIMURIUM (STM) EXPLOITS ASPECTS OF HOST IMMUNITY TO ESTABLISH A NICHE IN THE GUT AND OUTCOMPETE THE RESIDENT MICROBIOTA. DESPITE SIGNIFICANT PROGRESS IN UNDERSTANDING THE COMPETITIVE DYNAMICS BETWEEN STM AND THE GUT MICROBIOTA, THERE REMAIN GAPS IN OUR KNOWLEDGE REGARDING THE SPECIFIC MECHANISMS INVOLVED IN THEIR INTERACTIONS. HEREIN, WE PROPOSE A COMBINED APPROACH THAT INTEGRATES METAGENOMIC (METAG), METATRANSCRIPTOMIC (METAT), AND METATRANSLATOMIC (METARS) PROFILES TO ELUCIDATE NEW MECHANISTIC INTERACTIONS BETWEEN STM AND THE GUT MICROBIOTA. SPECIFICALLY, WE WILL USE QUANTITATIVE METAG, METAT, AND INTEGRATE INNOVATIVE COMMUNITY-LEVEL RIBOSOME FOOTPRINTING (METARS) TO CONSTRUCT A COMPREHENSIVE PROFILE OF RESOURCE ALLOCATION AND SUBSTRATE PREFERENCES WITHIN THE GUT MICROBIOTA. IT IS OUR EXPECTATION THAT THESE COMBINED APPROACHES WILL LEND INSIGHT INTO HOW METABOLIC NICHES ARE PERTURBED BY STM COLONIZATION AND ASSOCIATED HOST IMMUNE RESPONSES. THROUGH THE INTEGRATION OF THESE MULTIOMICS, WE HAVE GENERATED TESTABLE HYPOTHESES REGARDING POTENTIAL MECHANISMS OF COMPETITION BETWEEN STM AND THE GUT MICROBIOTA. WE INTEND TO TEST THESE HYPOTHESES IN THIS RESEARCH APPLICATION. OUR CENTRAL HYPOTHESIS IS THAT ELUCIDATING MICROBIAL METABOLISM IN THE GUT, IN CONJUNCTION WITH THE ANALYSIS OF HOST RESPONSES, WILL UNVEIL NEW COMPETITORS AND MECHANISMS OF COMPETITION BETWEEN STM AND THE GUT MICROBIOTA. WE WILL TEST OUR HYPOTHESIS BY PURSUING TWO SPECIFIC AIMS: IN AIM 1, WE WILL ANALYZE BACTERIAL METABOLISM TO IDENTIFY POTENTIAL SALMONELLA COMPETITORS IN MICE AND TEST THE PREDICTIONS IN VITRO AND IN VIVO. WE WILL VALIDATE THE PRELIMINARY FINDING THAT STM INFECTION DEPLETES SPECIFIC MEMBERS OF THE MICROBIOTA WITH SIMILAR METABOLIC PROFILES. WE WILL ALSO TEST THE PREDICTION THAT METABOLIC OVERLAP BETWEEN STM AND SPECIFIC MEMBERS OF THE MICROBIOTA REFLECTS COMPETITION FOR RESOURCES IN THE GUT. IN AIM 2, WE WILL INVESTIGATE WHETHER HOST ANTIMICROBIAL RESPONSES PROMOTE SALMONELLA COMPETITION WITH SELECTED MEMBERS OF THE GUT MICROBIOTA. COLLECTIVELY, THIS STUDY WILL PROVIDE A COMPREHENSIVE ANALYSIS OF BACTERIAL METABOLISM IN THE GUT AND HOW THIS IS PERTURBED IN THE CONTEXT OF STM INFECTION. MOREOVER, THE STUDY WILL TEST HYPOTHESES STEMMING FROM OUR PRELIMINARY DATA AS WELL AS GENERATE AND TEST NEW HYPOTHESES CONCERNING MECHANISMS GOVERNING MICROBIAL COMPETITION, ALSO IN THE CONTEXT OF HOST RESPONSES. MOVING FORWARD, THE INSIGHTS GARNERED FROM THIS RESEARCH HOLD PROMISE FOR THERAPEUTIC INTERVENTIONS AIMED AT REDUCING STM COLONIZATION AND REINSTATING INTESTINAL HOMEOSTASIS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 3/2/26 | ||
| Not listed | $178.3k | 3/11/25 | ||
| Not listed | $22.4k | 9/11/24 | ||
| Not listed | $22.4k | 9/11/24 | ||
| Not listed | $201.6k | 5/16/24 |