This Project Grant award of $1,491,931, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, supports research to identify the cellular targets and anti-inflammatory mechanisms by which GLP-1 receptor (GLP-1R) agonists reduce airway inflammation in both lean and obese patients with asthma. The overall objective is to inform the clinical repurposing of GLP-1R agonists, FDA-approved agents used for type 2 diabetes, obesity, and cardiovascular risk reduction, as a novel treatment strategy for asthma. The research will evaluate the role of GLP-1 signaling in regulating platelet-derived type 2 and non-type 2 inflammation, as well as CD4+ T cell function, in asthma patients. The award includes a sub-grant to Vanderbilt University's Sponsored Programs Administration to support this research. The project will run from Aug 16, 2024 to Jun 30, 2029.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $745.8k | 6/20/25 | ||
| Not listed | $74.6k | 9/17/24 | ||
| Not listed | $671.5k | 8/16/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
126356S | Vanderbilt University | Project Grant R01AI182159 | $5.8k | 11/1/24 |