The University of Vermont & State Agricultural College (UVM) received a $185,866 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports research to investigate the role of airway epithelial syndecan-1 (SDC1) cleavage by leukocyte-derived heparanases in driving inflammation, barrier dysfunction, and steroid resistance in a preclinical model of severe allergic asthma. The project will evaluate the effects of HDM-induced heparanase activity on mouse airway epithelial cell SDC1 cleavage, and determine if the anti-heparanase effects of capsaicin can alleviate these outcomes and restore corticosteroid sensitivity in the asthma model. The award has a performance period from February 1, 2025 to January 31, 2027.
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