This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $175,000.00 to the La Jolla Institute for Immunology to conduct research on the role of Alternaria fungal sensitization in asthma pathogenesis. The key research objectives are to: Determine the association between Alternaria-specific T cell subsets, including a novel "THIFNR" cell population, and protection...
This $760,759 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Illinois to examine the anti-inflammatory role of the CX3CR1+ conventional dendritic cell type 2 (CDC2) subset in resolving allergic lung inflammation associated with asthma. The key objectives are to characterize the mechanisms by which this CDC2 subset regulates regulatory T cell development and allergic inflammation...
This $468,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the regulation and function of tissue-resident eosinophils at steady state and during allergic disease. The key objectives are to: 1) Target cell cycle machinery to manipulate eosinophil specialization in mucosal tissue, 2) Delineate pre- and post-transcriptional events in eosinophil...
This $730,392 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the role of adipose tissue and eosinophils in regulating airway function and inflammation in lean and obese mouse models. The research aims to elucidate the mechanisms underlying the bidirectional communication between the lung and adipose tissue, particularly how adipose eosinophils...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) totaling $831,755 supports research to investigate the role of lung-resident macrophage subsets, particularly nerve- and airway-associated macrophages (NAMs), in regulating type 2 immune responses and tissue homeostasis. The research aims to elucidate the mechanisms by which these macrophage populations mediate protective...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to characterize a targetable stromal factor that alters immune cell accumulation in the lung and define the downstream effects on airway epithelial cells. The $636,843 award to the Regents of the University of California, San Francisco will utilize a combination of genetic tools, human organoid platforms, and a novel pharmacologic...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $320,863 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Aaiit LLC, a minority-owned for-profit company doing business as Inflammation Immuno Therapy, to develop a bifunctional IgE antagonist and dissociator (ANDI) drug. The ANDI drug is intended to improve lung function and reduce asthmatic exacerbations in patients with severe allergic asthma by removing IgE bound to mast...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $586,250 to the University of Massachusetts Medical School (UMass Medical) to elucidate the pathways that lead to the differentiation of TFH13 cells, a novel T cell subset that drives the production of high-affinity, pathogenic IgE antibodies in allergic diseases. The overarching goal is to determine the distinct...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research into the role of immunoglobulin E (IgE) and the sugar-binding protein galectin-3 in the activation of basophils, which play a key role in allergic reactions. The $162,728 award, granted to The Johns Hopkins University, aims to investigate the mechanisms by which galectin-3 can activate basophils independently of allergen...
This federal Project Grant award, titled "SENSORY NEURONAL MECHANISM FOR DEVELOPMENT OF HOUSE DUST MITE INDUCED AIRWAY HYPERREACTIVITY", is funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The $387,116 award will support research at the University of South Florida to investigate the sensory nerve mechanisms that contribute to airway hyperreactivity induced by house dust mites, a common...