Project Grant R01AI179714
- This $743,651 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to validate the use of plasma cell-free RNA (cfRNA) as a biomarker for the diagnosis of tuberculosis (TB) and monitoring of treatment. The grant will support the validation of cfRNA signatures in a large patient cohort of 1,378 adults across five countries, and the comparison of cfRNA diagnostic accuracy against...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to leverage antibody-omics to prevent and detect tuberculosis (TB) in children affected by HIV. The $209,750 award supports research to define antibody features associated with protection from Mycobacterium tuberculosis (MTB) infection among HIV-exposed infants (Aim 1) and identify biomarkers for active TB and MTB...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $1,265,657 to the Regents of the University of California, San Francisco (UCSF) to conduct a randomized trial to determine optimal tuberculosis (TB) screening and preventive therapy delivery strategies to improve maternal and birth outcomes among pregnant women with HIV in Uganda. The study aims to evaluate the effectiveness of using C-reactive protein (CRP) screening...
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $212,636 to Socios En Salud Sucursal Peru, a non-profit healthcare organization in Peru. The grant supports the development of tools to help primary care physicians in low- and middle-income countries better identify child and adolescent tuberculosis (TB) household contacts who require further...
- This Project Grant award of $781,129 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a 5-year study to validate and extend an integrated host-microbe (IHM) diagnostic approach for accurately diagnosing lower respiratory tract infections (LRTIs) in critically ill children. The study aims to: 1) validate the performance of the existing IHM LRTI diagnostic classifier, 2) develop a novel host gene expression...
- The federal Project Grant award of $3,089,360 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development and evaluation of innovative tuberculosis (TB) diagnostic platforms and assays. The 5-year project, awarded to Rutgers, The State University of New Jersey, aims to accelerate promising TB diagnostics through a fast-paced pipeline that includes technology scouting, development...
- This Project Grant award of $802,499, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855), aims to characterize the genetic factors involved in tuberculosis (TB) susceptibility and their interaction with the immune system. The key objectives are to: 1) generate population-level genetic data on 5,000 case-control samples from diverse South African populations to identify genetic markers associated...
- This Project Grant award in the amount of $431,712, funded by the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to improve HIV testing among children under five in rural Uganda. The primary goal is to engage with traditional healers to facilitate HIV counseling and testing via oral swab antigen tests for this vulnerable pediatric population. The award supports two key activities: 1) determining barriers and...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA program, will support research to investigate the use of chest radiography (CXR) to identify young individuals with early stages of tuberculosis (TB) in a community-based active case-finding program in Lima, Peru. The $242,376 award to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, will fund a 2-year study to...
- The National Institute of Allergy and Infectious Diseases (NIAID), through its Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $238,500 project grant to the University of California, San Diego (UC San Diego) to develop a novel electrochemical lateral flow assay (ELFA) for the point-of-need diagnosis of tuberculosis (TB). The objective is to create a highly sensitive and specific blood or urine test that can accurately distinguish active TB disease from...
CRISPR-TB FOR PEDIATRIC TB DIAGNOSIS AND TREATMENT RESPONSE - PROJECT SUMMARY/ABSTRACT CHILDREN UNDER 5 YEARS OF AGE ACCOUNT FOR ~50% OF THE 1.2 MILLION NEW CASES OF PEDIATRIC TB EACH YEAR, BUT ARE LEAST LIKELY TO BE DIAGNOSED, AND ARE AT HIGHEST RISK OF DEATH WITHOUT PROMPT TREATMENT. YOUNG CHILDREN ARE MORE LIKELY TO PRESENT WITH DISSEMINATED OR EXTRAPULMONARY TB AND PAUCIBACILLARY DISEASE, OFTEN MISSED BY RESPIRATORY SAMPLING AND OUR CURRENTLY AVAILABLE DIAGNOSTICS. NON-SPUTUM DIAGNOSTIC TOOLS FOR TB DETECTION AND TREATMENT RESPONSE IN YOUNG CHILDREN, USING EASILY OBTAINED SPECIMENS ARE URGENTLY NEEDED. OUR TEAM HAS SUCCESSFULLY DEVELOPED AN ULTRA-SENSITIVE CRISPR-BASED APPROACH (CRISPR-TB) THAT DETECTS M. TUBERCULOSIS (MTB) CELL FREE DNA (CFDNA). IN PILOT EVALUATION WITH REPOSITORY BLOOD SAMPLES, CRISPR-TB DEMONSTRATED HIGH SENSITIVITY (94%) AND SPECIFICITY (95%) AMONG ADULTS AND CHILDREN WITH TB AND THEIR ASYMPTOMATIC HOUSEHOLD CONTACTS IN ESWATINI. AMONG HOSPITALIZED KENYAN CHILDREN WITH HIV (MEDIAN AGE 2 YEARS), CRISPR-TB DETECTED 100% WITH MICROBIOLOGICALLY CONFIRMED TB, AND AN ADDITIONAL 85% WITH CLINICALLY DIAGNOSED TB (I.E. MISSED BY RESPIRATORY-BASED DIAGNOSTICS). WE NOW PROPOSE TO EXPAND CRISPR-TB EVALUATION IN A LARGE PROSPECTIVE COHORT OF 400 CHILDREN WITH SUSPECTED TB (MAJORITY
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $704.1k | 8/6/25 | ||
| Not listed | $71.4k | 9/4/24 | ||
| Not listed | $670.8k | 7/11/24 | ||
| Not listed | $670.8k | 7/11/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
UWSC15892S | The Administrators Of Tulane Educational Fund | Project Grant R01AI179714 | $275.4k | 2/24/25 | |
UWSC15911S | Kenya Medical Research Institute | Project Grant R01AI179714 | $129.5k | 1/29/25 |