This $209,750 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will leverage antibody-based approaches to prevent and detect tuberculosis (TB) in children affected by HIV. The key goals are to: 1) Define antibody Fc features associated with protection from Mycobacterium tuberculosis (MTB) infection in infants with and without maternal HIV exposure, and 2) Identify biomarkers for active TB and MTB infection compared to uninfected controls. The research will utilize specimen repositories from pediatric cohorts in Kenya, South Africa, India, and a multi-center IMPAACT study. The findings are expected to advance the development of innovative public health strategies, including new maternal/infant vaccines, monoclonal antibody therapies, and point-of-care testing for MTB infection and TB disease in high-burden settings. This multidisciplinary project capitalizes on Emory University's extensive expertise in humoral immunity, TB research, and assay development.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $209.8k | 5/22/25 |