Project Grant R01AG102889
- The National Institute on Aging awarded the University of Florida $540,345 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research into a metabolic sensor-driven metabolite repair system that maintains muscle stem cell homeostasis. The research addresses loss of skeletal muscle stem cell function as a central driver of impaired regeneration, progressive muscle wasting, and frailty in aging, muscular dystrophies, and metabolic diseases. The project investigates...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded Duke University $664,591 under the Aging Research program (CFDA 93.866) on September 1, 2026, to identify bioactive metabolites produced by beneficial gut bacteria and determine their mechanisms of action on host aging. The research applies a high-throughput, mass spectrometry-based pipeline to construct strain-specific metabolic profiles of human anaerobic gut bacteria, with particular focus on bifidobacteria. The project aims to identify...
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging awarded New York University $708,137 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate technologies for probing the biophysical properties of aging cells. The funded work centers on developing genetically encoded multimeric particles (GEMs) as high-throughput microrheology probes to measure the physical properties of cell interiors—particularly within organelles including the nucleus, cytoplasm, endoplasmic reticulum,...
- The National Institute on Aging awarded New York University $705,405 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how changes in nuclear physical properties during cellular senescence drive transcriptional and splicing dysregulation characteristic of aging. The funded research measures nuclear biophysical properties across multiple length scales using a toolkit including genetically encoded multimeric nanoparticles (nucGEMS, 40–50 nanometers), newly...
- The National Institute on Aging awarded Trustees Of Indiana University a Project Grant of $196,834 on August 1, 2026, to conduct metabolic characterization of skeletal muscle tissue in frail older adults under the Aging Research program (CFDA 93.866). The research will elucidate underlying metabolic deficiencies associated with physical frailty through comprehensive assessments of key bioenergetic pathways, including glycolysis, β-oxidation, the tricarboxylic acid cycle, the electron transport...
- The National Institute on Aging awarded Duke University $1.597 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research on epitranscriptomic regulation of microglia in Alzheimer's disease. The research investigates how m6a methylation of adenosine residues in messenger RNA regulates microglial cell function and transitions between resting and activated states during Alzheimer's disease pathogenesis, with the goal of identifying novel...
- The National Institute on Aging awarded The Leland Stanford Junior University $658,147 for Project Grant R01AG096626 on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research into mechanisms of skeletal muscle maintenance relevant to Alzheimer's disease and Alzheimer's disease-related dementia. The research examines how mitochondrial dysfunction, particularly reverse electron transport along mitochondrial complex I, contributes to NAD+ depletion during aging....
- The National Institute on Aging awarded Auburn University $166,152 on March 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of microRNA-1 in regulating pyruvate metabolism in patients with peripheral artery disease. The research addresses skeletal muscle metabolic dysfunction in PAD, a condition affecting 8–12 million Americans and 10–15 percent of the population age 65. The award supports investigation of how microRNA-1, the most abundant microRNA in skeletal...
The National Institute on Aging awarded Duke University $470,881 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate reductive tricarboxylic acid (TCA) cycle metabolism in muscle stem cell aging. The research examines glutamine metabolism pathways in muscle stem cells and how age-related dysfunction in these pathways impairs tissue regeneration. The project uses stable isotope-enabled metabolic flux analysis to characterize both oxidative and reductive glutamine metabolism routes. Preliminary data demonstrate that reductive pathways—mediated by isocitrate dehydrogenases 1 and 2 (IDH1/2)—support de novo lipogenesis and cell proliferation, while oxidative pathways generate energy. The study hypothesizes that age-related decline in glutaminase expression impairs these metabolic routes, and that restoring glutamine metabolism can reverse age-associated muscle stem cell dysfunction. Work proceeds through multiple aims testing the relative roles of oxidative and reductive pathways in satellite cell function and investigating whether age-related impairment is reversible. Performance occurs in Durham, North Carolina. The award is structured as a Project Grant, the standard assistance type for individual investigator-initiated research under the National Institute on Aging's aging research portfolio. The period of performance runs from the award date through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $470.9k | 8/11/26 |