Project Grant K22AG088211
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Indiana University Indianapolis $3,126,515 on August 15, 2025, under the Aging Research program (CFDA 93.866) to support research investigating a novel inter-tissue L-BAIBA/FGF23 (L-beta-aminoisobutyric acid/fibroblast growth factor 23) signaling axis as a therapeutic target for enhancing musculoskeletal remodeling in aging populations. The research project, with a completion date of May 31, 2029, will generate...
- The National Institute on Aging awarded Duke University $470,881 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate reductive tricarboxylic acid (TCA) cycle metabolism in muscle stem cell aging. The research examines glutamine metabolism pathways in muscle stem cells and how age-related dysfunction in these pathways impairs tissue regeneration. The project uses stable isotope-enabled metabolic flux analysis to characterize both oxidative and reductive glutamine...
- The National Institute on Aging awarded the University of Florida $540,345 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research into a metabolic sensor-driven metabolite repair system that maintains muscle stem cell homeostasis. The research addresses loss of skeletal muscle stem cell function as a central driver of impaired regeneration, progressive muscle wasting, and frailty in aging, muscular dystrophies, and metabolic diseases. The project investigates...
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging awarded Indiana University Indianapolis $109,795 on August 20, 2026, under the Aging Research program (CFDA 93.866) to evaluate amyloid dynamics and cerebral amyloid angiopathy burden. The project examines amyloid plaque redistribution and cerebral amyloid angiopathy development through genetic and pharmacological methods, and tests whether dietary and exercise interventions mitigate cerebral amyloid angiopathy burden. The research evaluates glial-based mechanisms...
- The National Institute on Aging awarded Trustees of Indiana University $433,593 on July 1, 2026, under the Aging Research program (CFDA 93.866) to integrate Centers for Medicare and Medicaid Services Medicare fee-for-service and Medicare Advantage inpatient data to improve hospital quality, outcomes, and disparities measurement. The project addresses a measurement gap created by Medicare Advantage enrollment growth to 55 percent of beneficiaries with Medicare Parts A and B coverage. Despite this...
- The National Institute on Aging awarded $431,996 to the Trustees of Indiana University, doing business as Indiana University Indianapolis, on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop and deliver INSPIRE (Investigating Neurosciences, A Summer Program to Ignite Research and Education), an immersive summer research education program designed to attract and retain undergraduate science majors pursuing careers in Alzheimer's disease and related dementias research....
- The National Institute on Aging awarded Auburn University $166,152 on March 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of microRNA-1 in regulating pyruvate metabolism in patients with peripheral artery disease. The research addresses skeletal muscle metabolic dysfunction in PAD, a condition affecting 8–12 million Americans and 10–15 percent of the population age 65. The award supports investigation of how microRNA-1, the most abundant microRNA in skeletal...
- The National Institute on Aging awarded Purdue University $387,183 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop mass spectrometry-based proteomics strategies examining post-translational modifications related to protein aggregation and extracellular vesicle-mediated propagation in neurodegenerative disease, with emphasis on Alzheimer's disease. The recipient will establish a novel proteomics platform to profile N-terminal acetylation landscapes in primary...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $2.78 million Project Grant to the Trustees of Indiana University (Indiana University Indianapolis) for research titled "Measuring Social Needs Among Older Adults: Psychometrics and Policy." The project, funded under the Aging Research program (CFDA 93.866) with a performance period from September 15, 2025, through September 14, 2029, addresses gaps in the measurement of health-related social needs (HRSNs)—also...
The National Institute on Aging awarded Trustees Of Indiana University a Project Grant of $196,834 on August 1, 2026, to conduct metabolic characterization of skeletal muscle tissue in frail older adults under the Aging Research program (CFDA 93.866). The research will elucidate underlying metabolic deficiencies associated with physical frailty through comprehensive assessments of key bioenergetic pathways, including glycolysis, β-oxidation, the tricarboxylic acid cycle, the electron transport chain, and the ATP–phosphocreatine energy system within frail and non-frail human skeletal muscle tissue. The investigation will employ targeted proteomics and ex vivo measures of mitochondrial function to quantitatively and qualitatively assess the metabolic capacity of frail skeletal muscle and identify novel skeletal muscle proteins associated with physical frailty. Study participants will include older men and women characterized as frail by the Fried criteria and non-frail age- and sex-matched healthy controls. The award period runs from August 1, 2026, through April 30, 2029, with place of performance in Maryland. Indiana University Indianapolis, doing business as the Trustees Of Indiana University, is the recipient institution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $196.8k | 7/31/26 |